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Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Dosa PI, Covel JA, Ren A, Webb RR, Beeley NR, Martin M, Morgan M, Espitia S, Saldana HR, Bjenning C, Whelan KT, Grottick AJ, Menzaghi F, Thomsen WJ. Smith BM, et al. Among authors: chen rr. J Med Chem. 2008 Jan 24;51(2):305-13. doi: 10.1021/jm0709034. Epub 2007 Dec 21. J Med Chem. 2008. PMID: 18095642
Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.
Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Thomsen WJ, Saldana HR, Whelan KT, Menzaghi F, Webb RR, Beeley NR. Smith BM, et al. Among authors: chen rr. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1467-70. doi: 10.1016/j.bmcl.2004.12.080. Bioorg Med Chem Lett. 2005. PMID: 15713408
Variant-specific antibody response following repeated SARS-CoV-2 vaccination and infection.
Jiang XL, Song XD, Shi C, Yang GJ, Wang XJ, Zhang YW, Wu J, Zhao LX, Zhang MZ, Wang MM, Chen RR, He XJ, Dai EH, Gao HX, Shen Y, Dong G, Wang YL, Ma MJ. Jiang XL, et al. Among authors: chen rr. Cell Rep. 2024 Jun 18;43(7):114387. doi: 10.1016/j.celrep.2024.114387. Online ahead of print. Cell Rep. 2024. PMID: 38896777 Free article.
182 results