Vigers G - Search Results

1

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

Thomas AA, Le Huerou Y, De Meese J, Gunawardana I, Kaplan T, Romoff TT, Gonzales SS, Condroski K, Boyd SA, Ballard J, Bernat B, DeWolf W, Han M, Lee P, Lemieux C, Pedersen R, Pheneger J, Poch G, Smith D, Sullivan F, Weiler S, Wright SK, Lin J, Brandhuber B, Vigers G. Thomas AA, et al. Among authors: vigers g. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2206-10. doi: 10.1016/j.bmcl.2007.11.101. Epub 2007 Dec 3. Bioorg Med Chem Lett. 2008. PMID: 18267359

2

Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1 beta by site-directed mutagenesis. Identification of a single site in IL-1ra and two sites in IL-1 beta.

Evans RJ, Bray J, Childs JD, Vigers GP, Brandhuber BJ, Skalicky JJ, Thompson RC, Eisenberg SP. Evans RJ, et al. Among authors: vigers gp. J Biol Chem. 1995 May 12;270(19):11477-83. doi: 10.1074/jbc.270.19.11477. J Biol Chem. 1995. PMID: 7744786 Free article.

3

X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution.

Vigers GP, Caffes P, Evans RJ, Thompson RC, Eisenberg SP, Brandhuber BJ. Vigers GP, et al. J Biol Chem. 1994 Apr 29;269(17):12874-9. J Biol Chem. 1994. PMID: 8175703 Free article.

4

Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.

Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ. Vigers GP, et al. Nature. 1997 Mar 13;386(6621):190-4. doi: 10.1038/386190a0. Nature. 1997. PMID: 9062193

5

Potent selective nonpeptidic inhibitors of human lung tryptase.

Burgess LE, Newhouse BJ, Ibrahim P, Rizzi J, Kashem MA, Hartman A, Brandhuber BJ, Wright CD, Thomson DS, Vigers GP, Koch K. Burgess LE, et al. Among authors: vigers gp. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8348-52. doi: 10.1073/pnas.96.15.8348. Proc Natl Acad Sci U S A. 1999. PMID: 10411878 Free PMC article.

6

X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1.

Vigers GP, Dripps DJ, Edwards CK 3rd, Brandhuber BJ. Vigers GP, et al. J Biol Chem. 2000 Nov 24;275(47):36927-33. doi: 10.1074/jbc.M006071200. J Biol Chem. 2000. PMID: 10903327 Free article.

7

Multiple active site corrections for docking and virtual screening.

Vigers GP, Rizzi JP. Vigers GP, et al. J Med Chem. 2004 Jan 1;47(1):80-9. doi: 10.1021/jm030161o. J Med Chem. 2004. PMID: 14695822

8

Non-charged thiamine analogs as inhibitors of enzyme transketolase.

Thomas AA, De Meese J, Le Huerou Y, Boyd SA, Romoff TT, Gonzales SS, Gunawardana I, Kaplan T, Sullivan F, Condroski K, Lyssikatos JP, Aicher TD, Ballard J, Bernat B, DeWolf W, Han M, Lemieux C, Smith D, Weiler S, Wright SK, Vigers G, Brandhuber B. Thomas AA, et al. Among authors: vigers g. Bioorg Med Chem Lett. 2008 Jan 15;18(2):509-12. doi: 10.1016/j.bmcl.2007.11.098. Epub 2007 Dec 3. Bioorg Med Chem Lett. 2008. PMID: 18182286

9

Potent and selective pyrazole-based inhibitors of B-Raf kinase.

Hansen JD, Grina J, Newhouse B, Welch M, Topalov G, Littman N, Callejo M, Gloor S, Martinson M, Laird E, Brandhuber BJ, Vigers G, Morales T, Woessner R, Randolph N, Lyssikatos J, Olivero A. Hansen JD, et al. Among authors: vigers g. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4692-5. doi: 10.1016/j.bmcl.2008.07.002. Epub 2008 Jul 5. Bioorg Med Chem Lett. 2008. PMID: 18676143

10

Discovery of pyrrolopyrimidine inhibitors of Akt.

Blake JF, Kallan NC, Xiao D, Xu R, Bencsik JR, Skelton NJ, Spencer KL, Mitchell IS, Woessner RD, Gloor SL, Risom T, Gross SD, Martinson M, Morales TH, Vigers GP, Brandhuber BJ. Blake JF, et al. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5607-12. doi: 10.1016/j.bmcl.2010.08.053. Epub 2010 Aug 13. Bioorg Med Chem Lett. 2010. PMID: 20810279

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