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Page 1
Decreased venous thrombosis with an oral inhibitor of P selectin.
Myers DD Jr, Rectenwald JE, Bedard PW, Kaila N, Shaw GD, Schaub RG, Farris DM, Hawley AE, Wrobleski SK, Henke PK, Wakefield TW. Myers DD Jr, et al. Among authors: kaila n. J Vasc Surg. 2005 Aug;42(2):329-36. doi: 10.1016/j.jvs.2005.04.045. J Vasc Surg. 2005. PMID: 16102635 Free article.
Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis.
Bedard PW, Clerin V, Sushkova N, Tchernychev B, Antrilli T, Resmini C, Keith JC Jr, Hennan JK, Kaila N, Debernardo S, Janz K, Wang Q, Crandall DL, Schaub RG, Shaw GD, Carter LL. Bedard PW, et al. Among authors: kaila n. J Pharmacol Exp Ther. 2008 Feb;324(2):497-506. doi: 10.1124/jpet.107.128124. Epub 2007 Nov 16. J Pharmacol Exp Ther. 2008. PMID: 18024786
Selectin inhibitors: a patent review.
Bedard PW, Kaila N. Bedard PW, et al. Among authors: kaila n. Expert Opin Ther Pat. 2010 Jun;20(6):781-93. doi: 10.1517/13543771003767468. Expert Opin Ther Pat. 2010. PMID: 20408735 Review.
Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
Huang A, Moretto A, Janz K, Lowe M, Bedard PW, Tam S, Di L, Clerin V, Sushkova N, Tchernychev B, Tsao DH, Keith JC, Shaw GD, Schaub RG, Wang Q, Kaila N. Huang A, et al. Among authors: kaila n. J Med Chem. 2010 Aug 26;53(16):6003-17. doi: 10.1021/jm9013696. J Med Chem. 2010. PMID: 20718494
2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.
Kaila N, Janz K, Huang A, Moretto A, DeBernardo S, Bedard PW, Tam S, Clerin V, Keith JC Jr, Tsao DH, Sushkova N, Shaw GD, Camphausen RT, Schaub RG, Wang Q. Kaila N, et al. J Med Chem. 2007 Jan 11;50(1):40-64. doi: 10.1021/jm060631p. J Med Chem. 2007. PMID: 17201409
Beta-C-mannosides as selectin inhibitors.
Kaila N, Chen L, Thomas BE 4th, Tsao D, Tam S, Bedard PW, Camphausen RT, Alvarez JC, Ullas G. Kaila N, et al. J Med Chem. 2002 Apr 11;45(8):1563-6. doi: 10.1021/jm010390f. J Med Chem. 2002. PMID: 11931610
41 results