Chen C - Search Results

1

Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse.

Dragin N, Shi Z, Madan R, Karp CL, Sartor MA, Chen C, Gonzalez FJ, Nebert DW. Dragin N, et al. Among authors: chen c. Mol Pharmacol. 2008 Jun;73(6):1844-56. doi: 10.1124/mol.108.045658. Epub 2008 Mar 27. Mol Pharmacol. 2008. PMID: 18372398 Free PMC article.

2

Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut.

Ito S, Chen C, Satoh J, Yim S, Gonzalez FJ. Ito S, et al. Among authors: chen c. J Clin Invest. 2007 Jul;117(7):1940-50. doi: 10.1172/JCI31647. J Clin Invest. 2007. PMID: 17607366 Free PMC article.

3

A metabolomic perspective of melatonin metabolism in the mouse.

Ma X, Chen C, Krausz KW, Idle JR, Gonzalez FJ. Ma X, et al. Among authors: chen c. Endocrinology. 2008 Apr;149(4):1869-79. doi: 10.1210/en.2007-1412. Epub 2008 Jan 10. Endocrinology. 2008. PMID: 18187545 Free PMC article.

4

Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).

Chen C, Meng L, Ma X, Krausz KW, Pommier Y, Idle JR, Gonzalez FJ. Chen C, et al. J Pharmacol Exp Ther. 2006 Sep;318(3):1330-42. doi: 10.1124/jpet.106.105213. Epub 2006 Jun 14. J Pharmacol Exp Ther. 2006. PMID: 16775196 Free PMC article.

5

Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity.

Abdelmegeed MA, Moon KH, Chen C, Gonzalez FJ, Song BJ. Abdelmegeed MA, et al. Among authors: chen c. Biochem Pharmacol. 2010 Jan 1;79(1):57-66. doi: 10.1016/j.bcp.2009.07.016. Epub 2009 Aug 4. Biochem Pharmacol. 2010. PMID: 19660437 Free PMC article.

6

Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.

Zhen Y, Krausz KW, Chen C, Idle JR, Gonzalez FJ. Zhen Y, et al. Among authors: chen c. Mol Endocrinol. 2007 Sep;21(9):2136-51. doi: 10.1210/me.2007-0150. Epub 2007 Jun 5. Mol Endocrinol. 2007. PMID: 17550978 Free PMC article.

7

A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.

Chen C, Ma X, Malfatti MA, Krausz KW, Kimura S, Felton JS, Idle JR, Gonzalez FJ. Chen C, et al. Chem Res Toxicol. 2007 Mar;20(3):531-42. doi: 10.1021/tx600320w. Epub 2007 Feb 6. Chem Res Toxicol. 2007. PMID: 17279779 Free PMC article.

8

Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX.

Meng LH, Shankavaram U, Chen C, Agama K, Fu HQ, Gonzalez FJ, Weinstein J, Pommier Y. Meng LH, et al. Among authors: chen c. Cancer Res. 2006 Oct 1;66(19):9656-64. doi: 10.1158/0008-5472.CAN-06-0796. Cancer Res. 2006. PMID: 17018623

9

Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice.

Chen C, Krausz KW, Idle JR, Gonzalez FJ. Chen C, et al. J Biol Chem. 2008 Feb 22;283(8):4543-59. doi: 10.1074/jbc.M706299200. Epub 2007 Dec 19. J Biol Chem. 2008. PMID: 18093979 Free PMC article.

10

LC-MS-based metabolomics in drug metabolism.

Chen C, Gonzalez FJ, Idle JR. Chen C, et al. Drug Metab Rev. 2007;39(2-3):581-97. doi: 10.1080/03602530701497804. Drug Metab Rev. 2007. PMID: 17786640 Free PMC article. Review.

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