Stokes ES - Search Results

1

Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors.

Andrews DM, Stokes ES, Carr GR, Matusiak ZS, Roberts CA, Waring MJ, Brady MC, Chresta CM, East SJ. Andrews DM, et al. Among authors: stokes es. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2580-4. doi: 10.1016/j.bmcl.2008.03.041. Epub 2008 Mar 16. Bioorg Med Chem Lett. 2008. PMID: 18378449

2

Design and campaign synthesis of pyridine-based histone deacetylase inhibitors.

Andrews DM, Gibson KM, Graham MA, Matusiak ZS, Roberts CA, Stokes ES, Brady MC, Chresta CM. Andrews DM, et al. Among authors: stokes es. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2525-9. doi: 10.1016/j.bmcl.2008.03.058. Epub 2008 Mar 22. Bioorg Med Chem Lett. 2008. PMID: 18378451

3

A biosynthetically-inspired synthesis of the tetrahydrofuran core of obtusallenes II and IV.

Braddock DC, Bhuva R, Millan DS, Pérez-Fuertes Y, Roberts CA, Sheppard RN, Solanki S, Stokes ES, White AJ. Braddock DC, et al. Among authors: stokes es. Org Lett. 2007 Feb 1;9(3):445-8. doi: 10.1021/ol062818g. Org Lett. 2007. PMID: 17249783

4

Quinuclidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase: optimization from lipid profiles.

Brown GR, Hollinshead DM, Stokes ES, Clarke DS, Eakin MA, Foubister AJ, Glossop SC, Griffiths D, Johnson MC, McTaggart F, Mirrlees DJ, Smith GJ, Wood R. Brown GR, et al. Among authors: stokes es. J Med Chem. 1999 Apr 8;42(7):1306-11. doi: 10.1021/jm990038q. J Med Chem. 1999. PMID: 10197973

5

A novel series of 4-piperidinopyridine and 4-piperidinopyrimidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase.

Brown GR, Hollinshead DM, Stokes ES, Waterson D, Clarke DS, Foubister AJ, Glossop SC, McTaggart F, Mirrlees DJ, Smith GJ, Wood R. Brown GR, et al. Among authors: stokes es. J Med Chem. 2000 Dec 28;43(26):4964-72. doi: 10.1021/jm000139k. J Med Chem. 2000. PMID: 11150166

6

Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors.

Hennequin LF, Stokes ES, Thomas AP, Johnstone C, Plé PA, Ogilvie DJ, Dukes M, Wedge SR, Kendrew J, Curwen JO. Hennequin LF, et al. Among authors: stokes es. J Med Chem. 2002 Mar 14;45(6):1300-12. doi: 10.1021/jm011022e. J Med Chem. 2002. PMID: 11881999

7

Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.

Hennequin LF, Thomas AP, Johnstone C, Stokes ES, Plé PA, Lohmann JJ, Ogilvie DJ, Dukes M, Wedge SR, Curwen JO, Kendrew J, Lambert-van der Brempt C. Hennequin LF, et al. Among authors: stokes es. J Med Chem. 1999 Dec 30;42(26):5369-89. doi: 10.1021/jm990345w. J Med Chem. 1999. PMID: 10639280

8

The stereochemical course of bromoetherification of enynes.

Christopher Braddock D, Bhuva R, Pérez-Fuertes Y, Pouwer R, Roberts CA, Ruggiero A, Stokes ES, White AJ. Christopher Braddock D, et al. Among authors: stokes es. Chem Commun (Camb). 2008 Mar 28;(12):1419-21. doi: 10.1039/b800054a. Epub 2008 Feb 20. Chem Commun (Camb). 2008. PMID: 18338042

9

ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.

Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Chester R, Jackson JA, Boffey SJ, Valentine PJ, Curwen JO, Musgrove HL, Graham GA, Hughes GD, Thomas AP, Stokes ES, Curry B, Richmond GH, Wadsworth PF, Bigley AL, Hennequin LF. Wedge SR, et al. Among authors: stokes es. Cancer Res. 2002 Aug 15;62(16):4645-55. Cancer Res. 2002. PMID: 12183421

10

ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy.

Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Curwen JO, Hennequin LF, Thomas AP, Stokes ES, Curry B, Richmond GH, Wadsworth PF. Wedge SR, et al. Among authors: stokes es. Cancer Res. 2000 Feb 15;60(4):970-5. Cancer Res. 2000. PMID: 10706112

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