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Structure and plasticity of the peptidyl-prolyl isomerase Par27 of Bordetella pertussis revealed by X-ray diffraction and small-angle X-ray scattering.
Clantin B, Leyrat C, Wohlkönig A, Hodak H, Ribeiro Ede A Jr, Martinez N, Baud C, Smet-Nocca C, Villeret V, Jacob-Dubuisson F, Jamin M. Clantin B, et al. Among authors: wohlkonig a. J Struct Biol. 2010 Mar;169(3):253-65. doi: 10.1016/j.jsb.2009.11.007. Epub 2009 Nov 20. J Struct Biol. 2010. PMID: 19932182
Allosteric nanobodies to study the interactions between SOS1 and RAS.
Fischer B, Uchański T, Sheryazdanova A, Gonzalez S, Volkov AN, Brosens E, Zögg T, Kalichuk V, Ballet S, Versées W, Sablina AA, Pardon E, Wohlkönig A, Steyaert J. Fischer B, et al. Among authors: wohlkonig a. Nat Commun. 2024 Jul 23;15(1):6214. doi: 10.1038/s41467-024-50349-2. Nat Commun. 2024. PMID: 39043660 Free PMC article.
Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Van Holsbeeck K, Fischer B, Gonzalez S, Gadais C, Versées W, Martins JC, Martin C, Wohlkönig A, Steyaert J, Ballet S. Van Holsbeeck K, et al. Among authors: wohlkonig a. Angew Chem Int Ed Engl. 2023 Jun 12;62(24):e202219095. doi: 10.1002/anie.202219095. Epub 2023 May 5. Angew Chem Int Ed Engl. 2023. PMID: 37067463
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Uchański T, Masiulis S, Fischer B, Kalichuk V, López-Sánchez U, Zarkadas E, Weckener M, Sente A, Ward P, Wohlkönig A, Zögg T, Remaut H, Naismith JH, Nury H, Vranken W, Aricescu AR, Pardon E, Steyaert J. Uchański T, et al. Among authors: wohlkonig a. Nat Methods. 2021 Jan;18(1):60-68. doi: 10.1038/s41592-020-01001-6. Epub 2021 Jan 6. Nat Methods. 2021. PMID: 33408403 Free PMC article.
Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity.
Villemagne B, Machelart A, Tran NC, Flipo M, Moune M, Leroux F, Piveteau C, Wohlkönig A, Wintjens R, Li X, Gref R, Brodin P, Deprez B, Baulard AR, Willand N. Villemagne B, et al. Among authors: wohlkonig a. ACS Infect Dis. 2020 Mar 13;6(3):366-378. doi: 10.1021/acsinfecdis.9b00277. Epub 2020 Mar 2. ACS Infect Dis. 2020. PMID: 32011115
Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility.
Yang D, Vandenbussche G, Vertommen D, Evrard D, Abskharon R, Cavalier JF, Berger G, Canaan S, Khan MS, Zeng S, Wohlkönig A, Prévost M, Soumillion P, Fontaine V. Yang D, et al. Among authors: wohlkonig a. FEBS Lett. 2020 Jan;594(1):79-93. doi: 10.1002/1873-3468.13555. Epub 2019 Aug 28. FEBS Lett. 2020. PMID: 31388991 Free article.
A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2.
Prevet H, Moune M, Tanina A, Kemmer C, Herledan A, Frita R, Wohlkönig A, Bourotte M, Villemagne B, Leroux F, Gitzinger M, Baulard AR, Déprez B, Wintjens R, Willand N, Flipo M. Prevet H, et al. Among authors: wohlkonig a. Eur J Med Chem. 2019 Apr 1;167:426-438. doi: 10.1016/j.ejmech.2019.02.023. Epub 2019 Feb 10. Eur J Med Chem. 2019. PMID: 30784877
44 results