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Functional activity of MD-2 polymorphic variant is significantly different in soluble and TLR4-bound forms: decreased endotoxin binding by G56R MD-2 and its rescue by TLR4 ectodomain.
J Immunol. 2008 May 1;180(9):6107-15. doi: 10.4049/jimmunol.180.9.6107.
J Immunol. 2008.
PMID: 18424732
Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4.
Prohinar P, Rallabhandi P, Weiss JP, Gioannini TL.
Prohinar P, et al.
J Immunol. 2010 Apr 15;184(8):4362-7. doi: 10.4049/jimmunol.0903142. Epub 2010 Mar 8.
J Immunol. 2010.
PMID: 20212095
Free PMC article.
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Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain.
Prohinar P, Re F, Widstrom R, Zhang D, Teghanemt A, Weiss JP, Gioannini TL.
Prohinar P, et al.
J Biol Chem. 2007 Jan 12;282(2):1010-7. doi: 10.1074/jbc.M609400200. Epub 2006 Nov 22.
J Biol Chem. 2007.
PMID: 17121827
Free article.
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Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase.
Gioannini TL, Teghanemt A, Zhang D, Prohinar P, Levis EN, Munford RS, Weiss JP.
Gioannini TL, et al. Among authors: prohinar p.
J Biol Chem. 2007 Mar 16;282(11):7877-84. doi: 10.1074/jbc.M605031200. Epub 2007 Jan 16.
J Biol Chem. 2007.
PMID: 17227775
Free article.
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Transfer of monomeric endotoxin from MD-2 to CD14: characterization and functional consequences.
Teghanemt A, Prohinar P, Gioannini TL, Weiss JP.
Teghanemt A, et al. Among authors: prohinar p.
J Biol Chem. 2007 Dec 14;282(50):36250-6. doi: 10.1074/jbc.M705995200. Epub 2007 Oct 13.
J Biol Chem. 2007.
PMID: 17934216
Free article.
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Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin.
Teghanemt A, Re F, Prohinar P, Widstrom R, Gioannini TL, Weiss JP.
Teghanemt A, et al. Among authors: prohinar p.
J Biol Chem. 2008 Jan 18;283(3):1257-1266. doi: 10.1074/jbc.M705994200. Epub 2007 Oct 30.
J Biol Chem. 2008.
PMID: 17977838
Free article.
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OmpR-dependent and OmpR-independent responses of Escherichia coli to sublethal attack by the neutrophil bactericidal/permeability increasing protein.
Prohinar P, Forst SA, Reed D, Mandic-Mulec I, Weiss J.
Prohinar P, et al.
Mol Microbiol. 2002 Mar;43(6):1493-504. doi: 10.1046/j.1365-2958.2002.02804.x.
Mol Microbiol. 2002.
PMID: 11952900
Free article.
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