Gioiello A - Search Results

1

Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5.

Macchiarulo A, Gioiello A, Thomas C, Massarotti A, Nuti R, Rosatelli E, Sabbatini P, Schoonjans K, Auwerx J, Pellicciari R. Macchiarulo A, et al. Among authors: gioiello a. J Chem Inf Model. 2008 Sep;48(9):1792-801. doi: 10.1021/ci800196h. Epub 2008 Aug 13. J Chem Inf Model. 2008. PMID: 18698841

2

Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.

Pellicciari R, Costantino G, Camaioni E, Sadeghpour BM, Entrena A, Willson TM, Fiorucci S, Clerici C, Gioiello A. Pellicciari R, et al. Among authors: gioiello a. J Med Chem. 2004 Aug 26;47(18):4559-69. doi: 10.1021/jm049904b. J Med Chem. 2004. PMID: 15317466

3

Molecular dynamics simulation of the ligand binding domain of farnesoid X receptor. Insights into helix-12 stability and coactivator peptide stabilization in response to agonist binding.

Costantino G, Entrena-Guadix A, Macchiarulo A, Gioiello A, Pellicciari R. Costantino G, et al. Among authors: gioiello a. J Med Chem. 2005 May 5;48(9):3251-9. doi: 10.1021/jm049182o. J Med Chem. 2005. PMID: 15857131

4

The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo.

Rizzo G, Disante M, Mencarelli A, Renga B, Gioiello A, Pellicciari R, Fiorucci S. Rizzo G, et al. Among authors: gioiello a. Mol Pharmacol. 2006 Oct;70(4):1164-73. doi: 10.1124/mol.106.023820. Epub 2006 Jun 15. Mol Pharmacol. 2006. PMID: 16778009

5

Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.

Pellicciari R, Gioiello A, Costantino G, Sadeghpour BM, Rizzo G, Meyer U, Parks DJ, Entrena-Guadix A, Fiorucci S. Pellicciari R, et al. Among authors: gioiello a. J Med Chem. 2006 Jul 13;49(14):4208-15. doi: 10.1021/jm060294k. J Med Chem. 2006. PMID: 16821780

6

Correlation between CMC and chromatographic index: simple and effective evaluation of the hydrophobic/hydrophilic balance of bile acids.

Natalini B, Sardella R, Camaioni E, Gioiello A, Pellicciari R. Natalini B, et al. Among authors: gioiello a. Anal Bioanal Chem. 2007 Aug;388(8):1681-8. doi: 10.1007/s00216-007-1360-6. Epub 2007 Jun 16. Anal Bioanal Chem. 2007. PMID: 17572887

7

Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.

Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, Auwerx J. Pellicciari R, et al. Among authors: gioiello a. J Med Chem. 2007 Sep 6;50(18):4265-8. doi: 10.1021/jm070633p. Epub 2007 Aug 9. J Med Chem. 2007. PMID: 17685603

8

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.

Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, Auwerx J. Sato H, et al. Among authors: gioiello a. J Med Chem. 2008 Mar 27;51(6):1831-41. doi: 10.1021/jm7015864. Epub 2008 Feb 29. J Med Chem. 2008. PMID: 18307294

9

Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids.

Natalini B, Sardella R, Camaioni E, Macchiarulo A, Gioiello A, Carbone G, Pellicciari R. Natalini B, et al. Among authors: gioiello a. J Pharm Biomed Anal. 2009 Nov 1;50(4):613-21. doi: 10.1016/j.jpba.2008.10.035. Epub 2008 Nov 6. J Pharm Biomed Anal. 2009. PMID: 19081222

10

BF(3).Et(2)O-induced decomposition of ethyl 2-diazo-3-hydroxy-3,3-diarylpropanoates in acetonitrile: a novel approach to 2,3-diaryl beta-enamino ester derivatives.

Gioiello A, Venturoni F, Natalini B, Pellicciari R. Gioiello A, et al. J Org Chem. 2009 May 1;74(9):3520-3. doi: 10.1021/jo802775q. J Org Chem. 2009. PMID: 19341244

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