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CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger WW, Drijfhout JW, Ossendorp F, Roep BO, Peakman M. Skowera A, et al. J Clin Invest. 2008 Oct;118(10):3390-402. doi: 10.1172/JCI35449. J Clin Invest. 2008. PMID: 18802479 Free PMC article.
Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture.
Allen JS, Pang K, Skowera A, Ellis R, Rackham C, Lozanoska-Ochser B, Tree T, Leslie RD, Tremble JM, Dayan CM, Peakman M. Allen JS, et al. Among authors: skowera a. Diabetes. 2009 Jan;58(1):138-45. doi: 10.2337/db08-0964. Epub 2008 Oct 3. Diabetes. 2009. PMID: 18835928 Free PMC article.
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes.
Yeo L, Woodwyk A, Sood S, Lorenc A, Eichmann M, Pujol-Autonell I, Melchiotti R, Skowera A, Fidanis E, Dolton GM, Tungatt K, Sewell AK, Heck S, Saxena A, Beam CA, Peakman M. Yeo L, et al. Among authors: skowera a. J Clin Invest. 2018 Aug 1;128(8):3460-3474. doi: 10.1172/JCI120555. Epub 2018 Jul 16. J Clin Invest. 2018. PMID: 29851415 Free PMC article. Clinical Trial.
Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells.
Kronenberg D, Knight RR, Estorninho M, Ellis RJ, Kester MG, de Ru A, Eichmann M, Huang GC, Powrie J, Dayan CM, Skowera A, van Veelen PA, Peakman M. Kronenberg D, et al. Among authors: skowera a. Diabetes. 2012 Jul;61(7):1752-9. doi: 10.2337/db11-1520. Epub 2012 Apr 20. Diabetes. 2012. PMID: 22522618 Free PMC article.
33 results