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Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.
Costanzo A, Guerrini G, Ciciani G, Bruni F, Costagli C, Selleri S, Besnard F, Costa B, Martini C, Malmberg-Aiello P. Costanzo A, et al. Among authors: selleri s. J Med Chem. 2002 Dec 19;45(26):5710-20. doi: 10.1021/jm020944u. J Med Chem. 2002. PMID: 12477354
Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy.
Guerrini G, Costanzo A, Ciciani G, Bruni F, Selleri S, Costagli C, Besnard F, Costa B, Martini C, De Siena G, Malmberg-Aiello P. Guerrini G, et al. Among authors: selleri s. Bioorg Med Chem. 2006 Feb 1;14(3):758-75. doi: 10.1016/j.bmc.2005.08.058. Epub 2005 Oct 7. Bioorg Med Chem. 2006. PMID: 16214350
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage.
Guerrini G, Ciciani G, Cambi G, Bruni F, Selleri S, Besnard F, Montali M, Martini C, Ghelardini C, Galeotti N, Costanzo A. Guerrini G, et al. Among authors: selleri s. Bioorg Med Chem. 2007 Apr 1;15(7):2573-86. doi: 10.1016/j.bmc.2007.01.053. Epub 2007 Feb 2. Bioorg Med Chem. 2007. PMID: 17306981
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies.
Guerrini G, Ciciani G, Cambi G, Bruni F, Selleri S, Melani F, Montali M, Martini C, Ghelardini C, Norcini M, Costanzo A. Guerrini G, et al. Among authors: selleri s. Bioorg Med Chem. 2008 Apr 15;16(8):4471-89. doi: 10.1016/j.bmc.2008.02.058. Epub 2008 Mar 5. Bioorg Med Chem. 2008. PMID: 18325771
Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism.
Guerrini G, Ciciani G, Cambi G, Bruni F, Selleri S, Guarino C, Melani F, Montali M, Martini C, Ghelardini C, Norcini M, Costanzo A. Guerrini G, et al. Among authors: selleri s. J Med Chem. 2009 Aug 13;52(15):4668-82. doi: 10.1021/jm801599a. J Med Chem. 2009. PMID: 19591485
158 results