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Page 1
Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors.
Wang Z, Cuddy M, Samuel T, Welsh K, Schimmer A, Hanaii F, Houghten R, Pinilla C, Reed JC. Wang Z, et al. Among authors: welsh k. J Biol Chem. 2004 Nov 12;279(46):48168-76. doi: 10.1074/jbc.M405022200. Epub 2004 Aug 27. J Biol Chem. 2004. PMID: 15337764 Free article.
A phenylurea series of chemical inhibitors of XIAP was recently generated by our laboratories (Schimmer, A. D., Welsh, K., Pinilla, C., Bonneau, M., Wang, Z., Pedersen, I. M., Scott, F. ...
A phenylurea series of chemical inhibitors of XIAP was recently generated by our laboratories (Schimmer, A. D., Welsh, K., Pin …
Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.
Crisóstomo FR, Feng Y, Zhu X, Welsh K, An J, Reed JC, Huang Z. Crisóstomo FR, et al. Among authors: welsh k. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6413-8. doi: 10.1016/j.bmcl.2009.09.058. Epub 2009 Sep 17. Bioorg Med Chem Lett. 2009. PMID: 19819692 Free PMC article.
Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
González-López M, Welsh K, Finlay D, Ardecky RJ, Ganji SR, Su Y, Yuan H, Teriete P, Mace PD, Riedl SJ, Vuori K, Reed JC, Cosford ND. González-López M, et al. Among authors: welsh k. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4332-6. doi: 10.1016/j.bmcl.2011.05.049. Epub 2011 May 24. Bioorg Med Chem Lett. 2011. PMID: 21680182 Free PMC article.
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
Ardecky RJ, Welsh K, Finlay D, Lee PS, González-López M, Ganji SR, Ravanan P, Mace PD, Riedl SJ, Vuori K, Reed JC, Cosford ND. Ardecky RJ, et al. Among authors: welsh k. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4253-7. doi: 10.1016/j.bmcl.2013.04.096. Epub 2013 May 14. Bioorg Med Chem Lett. 2013. PMID: 23743278 Free PMC article.
Peptides targeting caspase inhibitors.
Tamm I, Trepel M, Cardó-Vila M, Sun Y, Welsh K, Cabezas E, Swatterthwait A, Arap W, Reed JC, Pasqualini R. Tamm I, et al. Among authors: welsh k. J Biol Chem. 2003 Apr 18;278(16):14401-5. doi: 10.1074/jbc.M210133200. Epub 2003 Jan 21. J Biol Chem. 2003. PMID: 12538646 Free article.
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Schimmer AD, Welsh K, Pinilla C, Wang Z, Krajewska M, Bonneau MJ, Pedersen IM, Kitada S, Scott FL, Bailly-Maitre B, Glinsky G, Scudiero D, Sausville E, Salvesen G, Nefzi A, Ostresh JM, Houghten RA, Reed JC. Schimmer AD, et al. Among authors: welsh k. Cancer Cell. 2004 Jan;5(1):25-35. doi: 10.1016/s1535-6108(03)00332-5. Cancer Cell. 2004. PMID: 14749124 Free article.
Binding properties of the C-terminal domain of VIAF.
Bisson WH, Zhang Z, Welsh K, Huang JW, Ryan J, Reed JC, Pellecchia M. Bisson WH, et al. Among authors: welsh k. Chem Biol Drug Des. 2008 Nov;72(5):331-6. doi: 10.1111/j.1747-0285.2008.00719.x. Chem Biol Drug Des. 2008. PMID: 19012568
Vaccinia virus protein F1L is a caspase-9 inhibitor.
Zhai D, Yu E, Jin C, Welsh K, Shiau CW, Chen L, Salvesen GS, Liddington R, Reed JC. Zhai D, et al. Among authors: welsh k. J Biol Chem. 2010 Feb 19;285(8):5569-80. doi: 10.1074/jbc.M109.078113. Epub 2009 Dec 18. J Biol Chem. 2010. PMID: 20022954 Free PMC article.
637 results