Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.
Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I.
Ratan RR, et al. Among authors: sun d.
Ann N Y Acad Sci. 2008 Dec;1147:383-94. doi: 10.1196/annals.1427.033.
Ann N Y Acad Sci. 2008.
PMID: 19076458
Free PMC article.