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Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation.
Crouch PJ, Tew DJ, Du T, Nguyen DN, Caragounis A, Filiz G, Blake RE, Trounce IA, Soon CP, Laughton K, Perez KA, Li QX, Cherny RA, Masters CL, Barnham KJ, White AR. Crouch PJ, et al. Among authors: masters cl. J Neurochem. 2009 Mar;108(5):1198-207. doi: 10.1111/j.1471-4159.2009.05870.x. Epub 2009 Jan 7. J Neurochem. 2009. PMID: 19141082 Free article.
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Opazo C, et al. Among authors: masters cl. J Biol Chem. 2002 Oct 25;277(43):40302-8. doi: 10.1074/jbc.M206428200. Epub 2002 Aug 20. J Biol Chem. 2002. PMID: 12192006 Free article.
988 results