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1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia.
Anandan SK, Webb HK, Chen D, Wang YX, Aavula BR, Cases S, Cheng Y, Do ZN, Mehra U, Tran V, Vincelette J, Waszczuk J, White K, Wong KR, Zhang LN, Jones PD, Hammock BD, Patel DV, Whitcomb R, MacIntyre DE, Sabry J, Gless R. Anandan SK, et al. Among authors: patel dv. Bioorg Med Chem Lett. 2011 Feb 1;21(3):983-8. doi: 10.1016/j.bmcl.2010.12.042. Epub 2010 Dec 13. Bioorg Med Chem Lett. 2011. PMID: 21211973 Free PMC article.
N- and C-terminal modifications of negamycin.
Raju B, Mortell K, Anandan S, O'Dowd H, Gao H, Gomez M, Hackbarth C, Wu C, Wang W, Yuan Z, White R, Trias J, Patel DV. Raju B, et al. Among authors: patel dv. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2413-8. doi: 10.1016/s0960-894x(03)00393-7. Bioorg Med Chem Lett. 2003. PMID: 12824046
Conformationally restricted analogs of deoxynegamycin.
Raju B, Anandan S, Gu S, Herradura P, O'Dowd H, Kim B, Gomez M, Hackbarth C, Wu C, Wang W, Yuan Z, White R, Trias J, Patel DV. Raju B, et al. Among authors: patel dv. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3103-7. doi: 10.1016/j.bmcl.2004.04.036. Bioorg Med Chem Lett. 2004. PMID: 15149653
Novel oxazolidinone-quinolone hybrid antimicrobials.
Gordeev MF, Hackbarth C, Barbachyn MR, Banitt LS, Gage JR, Luehr GW, Gomez M, Trias J, Morin SE, Zurenko GE, Parker CN, Evans JM, White RJ, Patel DV. Gordeev MF, et al. Among authors: patel dv. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4213-6. doi: 10.1016/j.bmcl.2003.07.021. Bioorg Med Chem Lett. 2003. PMID: 14623004
342 results