Houghton AM - Search Results

1

Epithelial cell apoptosis causes acute lung injury masquerading as emphysema.

Mouded M, Egea EE, Brown MJ, Hanlon SM, Houghton AM, Tsai LW, Ingenito EP, Shapiro SD. Mouded M, et al. Among authors: houghton am. Am J Respir Cell Mol Biol. 2009 Oct;41(4):407-14. doi: 10.1165/rcmb.2008-0137OC. Epub 2009 Feb 2. Am J Respir Cell Mol Biol. 2009. PMID: 19188661 Free PMC article.

2

Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.

Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A. Shapiro SD, et al. Among authors: houghton am. Am J Pathol. 2003 Dec;163(6):2329-35. doi: 10.1016/S0002-9440(10)63589-4. Am J Pathol. 2003. PMID: 14633606 Free PMC article.

3

Elastin fragments drive disease progression in a murine model of emphysema.

Houghton AM, Quintero PA, Perkins DL, Kobayashi DK, Kelley DG, Marconcini LA, Mecham RP, Senior RM, Shapiro SD. Houghton AM, et al. J Clin Invest. 2006 Mar;116(3):753-9. doi: 10.1172/JCI25617. Epub 2006 Feb 9. J Clin Invest. 2006. PMID: 16470245 Free PMC article.

4

Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases.

Houghton AM, Grisolano JL, Baumann ML, Kobayashi DK, Hautamaki RD, Nehring LC, Cornelius LA, Shapiro SD. Houghton AM, et al. Cancer Res. 2006 Jun 15;66(12):6149-55. doi: 10.1158/0008-5472.CAN-04-0297. Cancer Res. 2006. PMID: 16778188

5

CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice.

Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD. Maeno T, et al. Among authors: houghton am. J Immunol. 2007 Jun 15;178(12):8090-6. doi: 10.4049/jimmunol.178.12.8090. J Immunol. 2007. PMID: 17548647

6

Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury.

Kaynar AM, Houghton AM, Lum EH, Pitt BR, Shapiro SD. Kaynar AM, et al. Among authors: houghton am. Am J Respir Cell Mol Biol. 2008 Jul;39(1):53-60. doi: 10.1165/rcmb.2007-0315OC. Epub 2008 Feb 14. Am J Respir Cell Mol Biol. 2008. PMID: 18276796 Free PMC article.

7

Common origins of lung cancer and COPD.

Houghton AM, Mouded M, Shapiro SD. Houghton AM, et al. Nat Med. 2008 Oct;14(10):1023-4. doi: 10.1038/nm1008-1023. Nat Med. 2008. PMID: 18841139 No abstract available.

8

Macrophage elastase kills bacteria within murine macrophages.

Houghton AM, Hartzell WO, Robbins CS, Gomis-Rüth FX, Shapiro SD. Houghton AM, et al. Nature. 2009 Jul 30;460(7255):637-41. doi: 10.1038/nature08181. Epub 2009 Jun 17. Nature. 2009. PMID: 19536155 Free PMC article.

9

Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.

Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD. Houghton AM, et al. Nat Med. 2010 Feb;16(2):219-23. doi: 10.1038/nm.2084. Epub 2010 Jan 17. Nat Med. 2010. PMID: 20081861 Free PMC article.

10

IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke.

Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JL, Keyser MR, Shapiro SD, Houghton AM, Kolls JK, Zheng M. Chen K, et al. Among authors: houghton am. PLoS One. 2011;6(5):e20333. doi: 10.1371/journal.pone.0020333. Epub 2011 May 27. PLoS One. 2011. PMID: 21647421 Free PMC article.

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