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Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein.
Tamagno E, Guglielmotto M, Aragno M, Borghi R, Autelli R, Giliberto L, Muraca G, Danni O, Zhu X, Smith MA, Perry G, Jo DG, Mattson MP, Tabaton M. Tamagno E, et al. Among authors: giliberto l. J Neurochem. 2008 Feb;104(3):683-95. doi: 10.1111/j.1471-4159.2007.05072.x. Epub 2007 Nov 14. J Neurochem. 2008. PMID: 18005001 Free PMC article.
Mutant presenilin 1 increases the expression and activity of BACE1.
Giliberto L, Borghi R, Piccini A, Mangerini R, Sorbi S, Cirmena G, Garuti A, Ghetti B, Tagliavini F, Mughal MR, Mattson MP, Zhu X, Wang X, Guglielmotto M, Tamagno E, Tabaton M. Giliberto L, et al. J Biol Chem. 2009 Apr 3;284(14):9027-38. doi: 10.1074/jbc.M805685200. Epub 2009 Feb 5. J Biol Chem. 2009. PMID: 19196715 Free PMC article.
Signaling effect of amyloid-beta(42) on the processing of AbetaPP.
Tabaton M, Zhu X, Perry G, Smith MA, Giliberto L. Tabaton M, et al. Among authors: giliberto l. Exp Neurol. 2010 Jan;221(1):18-25. doi: 10.1016/j.expneurol.2009.09.002. Epub 2009 Sep 9. Exp Neurol. 2010. PMID: 19747481 Free PMC article. Review.
41 results