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Page 1
Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.
Sakamoto T, Moriya M, Haga Y, Takahashi T, Shibata T, Okamoto O, Nonoshita K, Kitazawa H, Hidaka M, Gomori A, Iwaasa H, Ishihara A, Kanatani A, Fukami T, Gao YD, Macneil DJ, Yang L. Sakamoto T, et al. Among authors: gomori a. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1564-8. doi: 10.1016/j.bmcl.2009.02.035. Epub 2009 Feb 12. Bioorg Med Chem Lett. 2009. PMID: 19243937
Blockade of body weight gain and plasma corticosterone levels in Zucker fatty rats using an orally active neuropeptide Y Y1 antagonist.
Ishihara A, Kanatani A, Okada M, Hidaka M, Tanaka T, Mashiko S, Gomori A, Kanno T, Hata M, Kanesaka M, Tominaga Y, Sato NA, Kobayashi M, Murai T, Watanabe K, Ishii Y, Fukuroda T, Fukami T, Ihara M. Ishihara A, et al. Among authors: gomori a. Br J Pharmacol. 2002 Jun;136(3):341-6. doi: 10.1038/sj.bjp.0704696. Br J Pharmacol. 2002. PMID: 12023935 Free PMC article.
Characterization of MCH-mediated obesity in mice.
Ito M, Gomori A, Ishihara A, Oda Z, Mashiko S, Matsushita H, Yumoto M, Ito M, Sano H, Tokita S, Moriya M, Iwaasa H, Kanatani A. Ito M, et al. Among authors: gomori a. Am J Physiol Endocrinol Metab. 2003 May;284(5):E940-5. doi: 10.1152/ajpendo.00529.2002. Epub 2003 Jan 28. Am J Physiol Endocrinol Metab. 2003. PMID: 12554598 Free article.
A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice.
Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T, Ohe T, Guan X, MacNeil DJ, Van der Ploeg LH, Nishikibe M, Ishii Y, Ihara M, Fukami T. Ishihara A, et al. Among authors: gomori a. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7154-8. doi: 10.1073/pnas.0510320103. Epub 2006 Apr 24. Proc Natl Acad Sci U S A. 2006. PMID: 16636293 Free PMC article.
A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
Mashiko S, Ishihara A, Iwaasa H, Sano H, Ito J, Gomori A, Oda Z, Moriya R, Matsushita H, Jitsuoka M, Okamoto O, MacNeil DJ, Van der Ploeg LH, Fukami T, Kanatani A. Mashiko S, et al. Among authors: gomori a. Mol Pharmacol. 2007 Feb;71(2):602-8. doi: 10.1124/mol.106.029991. Epub 2006 Nov 14. Mol Pharmacol. 2007. PMID: 17105869
47 results