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The peptide Trp-Lys-Tyr-Met-Val-D-Met activates neutrophils through the formyl peptide receptor only when signaling through the formylpeptide receptor like 1 is blocked. A receptor switch with implications for signal transduction studies with inhibitors and receptor antagonists.
Karlsson J, Fu H, Boulay F, Bylund J, Dahlgren C. Karlsson J, et al. Biochem Pharmacol. 2006 May 14;71(10):1488-96. doi: 10.1016/j.bcp.2006.02.010. Epub 2006 Mar 6. Biochem Pharmacol. 2006. PMID: 16549058
The beta-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist.
Forsman H, Salomonsson E, Onnheim K, Karlsson J, Björstad A, Leffler H, Bylund J, Karlsson A, Dahlgren C. Forsman H, et al. Among authors: karlsson j, karlsson a. Glycobiology. 2008 Nov;18(11):905-12. doi: 10.1093/glycob/cwn081. Epub 2008 Aug 25. Glycobiology. 2008. PMID: 18725453
1,838 results