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Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts.
Phytother Res. 2009 Oct;23(10):1453-7. doi: 10.1002/ptr.2800.
Phytother Res. 2009.
PMID: 19288528
Central nervous system depressant action of flavonoid glycosides.
Fernández SP, Wasowski C, Loscalzo LM, Granger RE, Johnston GA, Paladini AC, Marder M.
Fernández SP, et al. Among authors: loscalzo lm.
Eur J Pharmacol. 2006 Jun 13;539(3):168-76. doi: 10.1016/j.ejphar.2006.04.004. Epub 2006 Apr 6.
Eur J Pharmacol. 2006.
PMID: 16698011
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Chronic intraperitoneal and oral treatments with hesperidin induce central nervous system effects in mice.
Wasowski C, Loscalzo LM, Higgs J, Marder M.
Wasowski C, et al. Among authors: loscalzo lm.
Phytother Res. 2012 Feb;26(2):308-12. doi: 10.1002/ptr.3560. Epub 2011 Jun 30.
Phytother Res. 2012.
PMID: 21717517
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Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.
Loscalzo LM, Wasowski C, Paladini AC, Marder M.
Loscalzo LM, et al.
Eur J Pharmacol. 2008 Feb 12;580(3):306-13. doi: 10.1016/j.ejphar.2007.11.011. Epub 2007 Nov 13.
Eur J Pharmacol. 2008.
PMID: 18048026
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Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice.
Martínez MC, Fernandez SP, Loscalzo LM, Wasowski C, Paladini AC, Marder M, Medina JH, Viola H.
Martínez MC, et al. Among authors: loscalzo lm.
Pharmacol Biochem Behav. 2009 Apr;92(2):291-6. doi: 10.1016/j.pbb.2008.12.016. Epub 2008 Dec 31.
Pharmacol Biochem Behav. 2009.
PMID: 19159642
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Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents.
Loscalzo LM, Yow TT, Wasowski C, Chebib M, Marder M.
Loscalzo LM, et al.
Pharmacol Biochem Behav. 2011 Sep;99(3):333-41. doi: 10.1016/j.pbb.2011.05.018. Epub 2011 May 23.
Pharmacol Biochem Behav. 2011.
PMID: 21624389
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In vitro binding affinities of a series of flavonoids for μ-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice.
Higgs J, Wasowski C, Loscalzo LM, Marder M.
Higgs J, et al. Among authors: loscalzo lm.
Neuropharmacology. 2013 Sep;72:9-19. doi: 10.1016/j.neuropharm.2013.04.020. Epub 2013 Apr 26.
Neuropharmacology. 2013.
PMID: 23624290
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