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Receptor occupancy and brain free fraction.
Watson J, Wright S, Lucas A, Clarke KL, Viggers J, Cheetham S, Jeffrey P, Porter R, Read KD. Watson J, et al. Among authors: lucas a. Drug Metab Dispos. 2009 Apr;37(4):753-60. doi: 10.1124/dmd.108.022814. Epub 2009 Jan 21. Drug Metab Dispos. 2009. PMID: 19158315
Toward an improved prediction of human in vivo brain penetration.
Summerfield SG, Lucas AJ, Porter RA, Jeffrey P, Gunn RN, Read KR, Stevens AJ, Metcalf AC, Osuna MC, Kilford PJ, Passchier J, Ruffo AD. Summerfield SG, et al. Among authors: lucas aj. Xenobiotica. 2008 Dec;38(12):1518-35. doi: 10.1080/00498250802499459. Xenobiotica. 2008. PMID: 18979396
The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists.
Johnson DJ, Forbes IT, Watson SP, Garzya V, Stevenson GI, Walker GR, Mudhar HS, Flynn ST, Wyman PA, Smith PW, Murkitt GS, Lucas AJ, Mookherjee CR, Watson JM, Gartlon JE, Bradford AM, Brown F. Johnson DJ, et al. Among authors: lucas aj. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5434-8. doi: 10.1016/j.bmcl.2010.07.097. Epub 2010 Jul 30. Bioorg Med Chem Lett. 2010. PMID: 20709550
1,959 results