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CD36 mediates the innate host response to beta-amyloid.
El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD. El Khoury JB, et al. J Exp Med. 2003 Jun 16;197(12):1657-66. doi: 10.1084/jem.20021546. Epub 2003 Jun 9. J Exp Med. 2003. PMID: 12796468 Free PMC article.
CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils.
Coraci IS, Husemann J, Berman JW, Hulette C, Dufour JH, Campanella GK, Luster AD, Silverstein SC, El-Khoury JB. Coraci IS, et al. Among authors: el khoury jb. Am J Pathol. 2002 Jan;160(1):101-12. doi: 10.1016/s0002-9440(10)64354-4. Am J Pathol. 2002. PMID: 11786404 Free PMC article.
Neuroinflammation in Alzheimer's disease.
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Heneka MT, et al. Among authors: el khoury j. Lancet Neurol. 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5. Lancet Neurol. 2015. PMID: 25792098 Free PMC article. Review.
261 results