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A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy.
Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, Horn-Saban S, Amann-Zalcenstein D, Raanan C, Berkutzki T, Erez-Roman R, Ben-David O, Levy M, Holzman D, Park H, Nyska A, Merrill AH Jr, Futerman AH. Pewzner-Jung Y, et al. Among authors: laviad el. J Biol Chem. 2010 Apr 2;285(14):10911-23. doi: 10.1074/jbc.M109.077610. Epub 2010 Jan 28. J Biol Chem. 2010. PMID: 20110366 Free PMC article.
Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.
Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH Jr, Futerman AH. Ben-David O, et al. Among authors: laviad el. J Biol Chem. 2011 Aug 26;286(34):30022-33. doi: 10.1074/jbc.M111.261206. Epub 2011 Jun 24. J Biol Chem. 2011. PMID: 21705317 Free PMC article.
Modulation of ceramide synthase activity via dimerization.
Laviad EL, Kelly S, Merrill AH Jr, Futerman AH. Laviad EL, et al. J Biol Chem. 2012 Jun 15;287(25):21025-33. doi: 10.1074/jbc.M112.363580. Epub 2012 Apr 26. J Biol Chem. 2012. PMID: 22539345 Free PMC article.
Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum.
Hullin-Matsuda F, Tomishige N, Sakai S, Ishitsuka R, Ishii K, Makino A, Greimel P, Abe M, Laviad EL, Lagarde M, Vidal H, Saito T, Osada H, Hanada K, Futerman AH, Kobayashi T. Hullin-Matsuda F, et al. Among authors: laviad el. J Biol Chem. 2012 Jul 13;287(29):24397-411. doi: 10.1074/jbc.M112.344432. Epub 2012 May 17. J Biol Chem. 2012. PMID: 22605339 Free PMC article.
15 results