Walker DK - Search Results

1

SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data.

Mantell SJ, Stephenson PT, Monaghan SM, Maw GN, Trevethick MA, Yeadon M, Walker DK, Selby MD, Batchelor DV, Rozze S, Chavaroche H, Lemaitre A, Wright KN, Whitlock L, Stuart EF, Wright PA, Macintyre F. Mantell SJ, et al. Among authors: walker dk. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4471-5. doi: 10.1016/j.bmcl.2009.05.027. Epub 2009 May 12. Bioorg Med Chem Lett. 2009. PMID: 19501510

2

Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease.

Mantell SJ, Stephenson PT, Monaghan SM, Maw GN, Trevethick MA, Yeadon M, Keir RF, Walker DK, Jones RM, Selby MD, Batchelor DV, Rozze S, Chavaroche H, Hobson TJ, Dodd PG, Lemaitre A, Wright KN, Stuart EF. Mantell SJ, et al. Among authors: walker dk. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1284-7. doi: 10.1016/j.bmcl.2008.01.033. Epub 2008 Jan 12. Bioorg Med Chem Lett. 2008. PMID: 18243699

3

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man.

Walker DK, Ackland MJ, James GC, Muirhead GJ, Rance DJ, Wastall P, Wright PA. Walker DK, et al. Xenobiotica. 1999 Mar;29(3):297-310. doi: 10.1080/004982599238687. Xenobiotica. 1999. PMID: 10219969 Clinical Trial.

4

Property-based design: optimization of drug absorption and pharmacokinetics.

van De Waterbeemd H, Smith DA, Beaumont K, Walker DK. van De Waterbeemd H, et al. Among authors: walker dk. J Med Chem. 2001 Apr 26;44(9):1313-33. doi: 10.1021/jm000407e. J Med Chem. 2001. PMID: 11311053 Review. No abstract available.

5

Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog.

Walker DK, Beaumont KC, Comby P, Evans KM, Gedge JI, Halliday RC, Roffey SJ, Wright PA. Walker DK, et al. Xenobiotica. 2001 Aug-Sep;31(8-9):651-64. doi: 10.1080/00498250110056522. Xenobiotica. 2001. PMID: 11569531

6

Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics.

Smith DA, Jones BC, Walker DK. Smith DA, et al. Among authors: walker dk. Med Res Rev. 1996 May;16(3):243-66. doi: 10.1002/(SICI)1098-1128(199605)16:3<243::AID-MED2>3.0.CO;2-Z. Med Res Rev. 1996. PMID: 8727426 Review.

7

The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development.

Walker DK. Walker DK. Br J Clin Pharmacol. 2004 Dec;58(6):601-8. doi: 10.1111/j.1365-2125.2004.02194.x. Br J Clin Pharmacol. 2004. PMID: 15563358 Free PMC article. Review.

8

Pharmacokinetics and clearance processes of UK-279,276 (rNIF) in rat and dog: comparison with human data.

Webster R, Edgington A, Phipps J, Walker D. Webster R, et al. Xenobiotica. 2006 Apr;36(4):341-9. doi: 10.1080/00498250600630941. Xenobiotica. 2006. PMID: 16684713

9

Absorption, distribution, metabolism, and excretion considerations in selection of orally active indole-containing endothelin antagonist.

Walker DK, Dack KN, Dickinson RP, Fenner KS, James K, Rawson DJ, Smith DA. Walker DK, et al. Drug Metab Dispos. 2001 Nov;29(11):1424-31. Drug Metab Dispos. 2001. PMID: 11602517

10

The use of C(av) rather than AUC in safety assessment.

Smith DA, Morgan P, Vogel WM, Walker DK. Smith DA, et al. Among authors: walker dk. Regul Toxicol Pharmacol. 2010 Jun;57(1):70-3. doi: 10.1016/j.yrtph.2010.01.001. Epub 2010 Jan 13. Regul Toxicol Pharmacol. 2010. PMID: 20074607

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

197 results

Search Page