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Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo.
Zhang H, Xu X, Gajewiak J, Tsukahara R, Fujiwara Y, Liu J, Fells JI, Perygin D, Parrill AL, Tigyi G, Prestwich GD. Zhang H, et al. Among authors: parrill al. Cancer Res. 2009 Jul 1;69(13):5441-9. doi: 10.1158/0008-5472.CAN-09-0302. Epub 2009 Jun 9. Cancer Res. 2009. PMID: 19509223 Free PMC article.
Molecular mechanisms of lysophosphatidic acid action.
Tigyi G, Parrill AL. Tigyi G, et al. Among authors: parrill al. Prog Lipid Res. 2003 Nov;42(6):498-526. doi: 10.1016/s0163-7827(03)00035-3. Prog Lipid Res. 2003. PMID: 14559069 Review. No abstract available.
Identification of non-lipid LPA3 antagonists by virtual screening.
Fells JI, Tsukahara R, Fujiwara Y, Liu J, Perygin DH, Osborne DA, Tigyi G, Parrill AL. Fells JI, et al. Among authors: parrill al. Bioorg Med Chem. 2008 Jun 1;16(11):6207-17. doi: 10.1016/j.bmc.2008.04.035. Epub 2008 Apr 18. Bioorg Med Chem. 2008. PMID: 18467108 Free PMC article.
Structure-based drug design identifies novel LPA3 antagonists.
Fells JI, Tsukahara R, Liu J, Tigyi G, Parrill AL. Fells JI, et al. Among authors: parrill al. Bioorg Med Chem. 2009 Nov 1;17(21):7457-64. doi: 10.1016/j.bmc.2009.09.022. Epub 2009 Sep 18. Bioorg Med Chem. 2009. PMID: 19800804 Free PMC article.
2D binary QSAR modeling of LPA3 receptor antagonism.
Fells JI, Tsukahara R, Liu J, Tigyi G, Parrill AL. Fells JI, et al. Among authors: parrill al. J Mol Graph Model. 2010 Jun;28(8):828-33. doi: 10.1016/j.jmgm.2010.03.002. Epub 2010 Mar 7. J Mol Graph Model. 2010. PMID: 20356772 Free PMC article.
Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.
Gupte R, Patil R, Liu J, Wang Y, Lee SC, Fujiwara Y, Fells J, Bolen AL, Emmons-Thompson K, Yates CR, Siddam A, Panupinthu N, Pham TC, Baker DL, Parrill AL, Mills GB, Tigyi G, Miller DD. Gupte R, et al. Among authors: parrill al. ChemMedChem. 2011 May 2;6(5):922-35. doi: 10.1002/cmdc.201000425. Epub 2011 Apr 4. ChemMedChem. 2011. PMID: 21465666 Free PMC article.
Molecular basis for lysophosphatidic acid receptor antagonist selectivity.
Sardar VM, Bautista DL, Fischer DJ, Yokoyama K, Nusser N, Virag T, Wang DA, Baker DL, Tigyi G, Parrill AL. Sardar VM, et al. Among authors: parrill al. Biochim Biophys Acta. 2002 May 23;1582(1-3):309-17. doi: 10.1016/s1388-1981(02)00185-3. Biochim Biophys Acta. 2002. PMID: 12069842 Review.
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Fells JI, Lee SC, Fujiwara Y, Norman DD, Lim KG, Tsukahara R, Liu J, Patil R, Miller DD, Kirby RJ, Nelson S, Seibel W, Papoian R, Parrill AL, Baker DL, Bittman R, Tigyi G. Fells JI, et al. Among authors: parrill al. Mol Pharmacol. 2013 Sep;84(3):415-24. doi: 10.1124/mol.113.087080. Epub 2013 Jun 21. Mol Pharmacol. 2013. PMID: 23793291 Free PMC article.
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