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Phase I clinical studies of the advanced glycation end-product (AGE)-breaker TRC4186: safety, tolerability and pharmacokinetics in healthy subjects.
Clin Drug Investig. 2009;29(9):559-75. doi: 10.2165/11315260-000000000-00000.
Clin Drug Investig. 2009.
PMID: 19663519
Clinical Trial.
TRC4186, a novel AGE-breaker, improves diabetic cardiomyopathy and nephropathy in Ob-ZSF1 model of type 2 diabetes.
Joshi D, Gupta R, Dubey A, Shiwalkar A, Pathak P, Gupta RC, Chauthaiwale V, Dutt C.
Joshi D, et al. Among authors: shiwalkar a.
J Cardiovasc Pharmacol. 2009 Jul;54(1):72-81. doi: 10.1097/FJC.0b013e3181ac3a34.
J Cardiovasc Pharmacol. 2009.
PMID: 19546815
Item in Clipboard
Safety, Tolerability, and Pharmacokinetics of a Novel Mitochondrial Modulator, TRC150094, in Overweight and Obese Subjects: A Randomized Phase-I Clinical Trial.
Joshi D, Jamadarkhana P, Kumbhare S, Singh A, Kotecha J, Bunger D, Shiwalkar A, Mohanan A, Dutt C.
Joshi D, et al. Among authors: shiwalkar a.
Front Pharmacol. 2021 Sep 17;12:729424. doi: 10.3389/fphar.2021.729424. eCollection 2021.
Front Pharmacol. 2021.
PMID: 34603045
Free PMC article.
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TRC4149 a novel advanced glycation end product breaker improves hemodynamic status in diabetic spontaneously hypertensive rats.
Pathak P, Gupta R, Chaudhari A, Shiwalkar A, Dubey A, Mandhare AB, Gupta RC, Joshi D, Chauthaiwale V.
Pathak P, et al. Among authors: shiwalkar a.
Eur J Med Res. 2008 Aug 18;13(8):388-98.
Eur J Med Res. 2008.
PMID: 18952522
Item in Clipboard
Continuous, non-invasive measurement of the haemodynamic response to submaximal exercise in patients with diabetes mellitus: evidence of impaired cardiac reserve and peripheral vascular response.
Joshi D, Shiwalkar A, Cross MR, Sharma SK, Vachhani A, Dutt C.
Joshi D, et al. Among authors: shiwalkar a.
Heart. 2010 Jan;96(1):36-41. doi: 10.1136/hrt.2009.177113. Epub 2009 Oct 22.
Heart. 2010.
PMID: 19850585
Free PMC article.
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Computational modeling of bone density profiles in response to gait: a subject-specific approach.
Pang H, Shiwalkar AP, Madormo CM, Taylor RE, Andriacchi TP, Kuhl E.
Pang H, et al. Among authors: shiwalkar ap.
Biomech Model Mechanobiol. 2012 Mar;11(3-4):379-90. doi: 10.1007/s10237-011-0318-y. Epub 2011 May 22.
Biomech Model Mechanobiol. 2012.
PMID: 21604146
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