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Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations.
Biochem Pharmacol. 2010 Jan 15;79(2):102-11. doi: 10.1016/j.bcp.2009.07.025. Epub 2009 Aug 7.
Biochem Pharmacol. 2010.
PMID: 19665450
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
Jiang Y, Han J, Yu C, Vass SO, Searle PF, Browne P, Knox RJ, Hu L.
Jiang Y, et al. Among authors: vass so.
J Med Chem. 2006 Jul 13;49(14):4333-43. doi: 10.1021/jm051246n.
J Med Chem. 2006.
PMID: 16821793
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E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954.
Vass SO, Jarrom D, Wilson WR, Hyde EI, Searle PF.
Vass SO, et al.
Br J Cancer. 2009 Jun 16;100(12):1903-11. doi: 10.1038/sj.bjc.6605094. Epub 2009 May 19.
Br J Cancer. 2009.
PMID: 19455141
Free PMC article.
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Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.
Hu L, Wu X, Han J, Chen L, Vass SO, Browne P, Hall BS, Bot C, Gobalakrishnapillai V, Searle PF, Knox RJ, Wilkinson SR.
Hu L, et al. Among authors: vass so.
Bioorg Med Chem Lett. 2011 Jul 1;21(13):3986-91. doi: 10.1016/j.bmcl.2011.05.009. Epub 2011 May 7.
Bioorg Med Chem Lett. 2011.
PMID: 21620697
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Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Day MA, Christofferson AJ, Anderson JLR, Vass SO, Evans A, Searle PF, White SA, Hyde EI.
Day MA, et al. Among authors: vass so.
Int J Mol Sci. 2023 Mar 22;24(6):5987. doi: 10.3390/ijms24065987.
Int J Mol Sci. 2023.
PMID: 36983061
Free PMC article.
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