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Page 1
Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs.
Ahmad S, Doweyko L, Ashfaq A, Ferrara FN, Bisaha SN, Schmidt JB, DiMarco J, Conder ML, Jenkins-West T, Normandin DE, Russell AD, Smith MA, Levesque PC, Lodge NJ, Lloyd J, Stein PD, Atwal KS. Ahmad S, et al. Among authors: jenkins west t. Bioorg Med Chem Lett. 2004 Jan 5;14(1):99-102. doi: 10.1016/j.bmcl.2003.10.003. Bioorg Med Chem Lett. 2004. PMID: 14684307
Benzopyran sulfonamides as KV1.5 potassium channel blockers.
Lloyd J, Atwal KS, Finlay HJ, Nyman M, Huynh T, Bhandaru R, Kover A, Schmidt J, Vaccaro W, Conder ML, Jenkins-West T, Levesque P. Lloyd J, et al. Among authors: jenkins west t. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3271-5. doi: 10.1016/j.bmcl.2007.04.020. Epub 2007 Apr 10. Bioorg Med Chem Lett. 2007. PMID: 17462888
Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)).
Vaccaro W, Huynh T, Lloyd J, Atwal K, Finlay HJ, Levesque P, Conder ML, Jenkins-West T, Shi H, Sun L. Vaccaro W, et al. Among authors: jenkins west t. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6381-5. doi: 10.1016/j.bmcl.2008.10.099. Epub 2008 Oct 25. Bioorg Med Chem Lett. 2008. PMID: 19004630
Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers.
Lloyd J, Finlay HJ, Vacarro W, Hyunh T, Kover A, Bhandaru R, Yan L, Atwal K, Conder ML, Jenkins-West T, Shi H, Huang C, Li D, Sun H, Levesque P. Lloyd J, et al. Among authors: jenkins west t. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1436-9. doi: 10.1016/j.bmcl.2009.12.085. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20097068
Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers.
Lloyd J, Schmidt JB, Rovnyak G, Ahmad S, Atwal KS, Bisaha SN, Doweyko LM, Stein PD, Traeger SC, Mathur A, Conder ML, DiMarco J, Harper TW, Jenkins-West T, Levesque PC, Normandin DE, Russell AD, Serafino RP, Smith MA, Lodge NJ. Lloyd J, et al. Among authors: jenkins west t. J Med Chem. 2001 Nov 8;44(23):3764-7. doi: 10.1021/jm015505u. J Med Chem. 2001. PMID: 11689063