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Page 1
Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors.
Heim-Riether A, Taylor SJ, Liang S, Gao DA, Xiong Z, Michael August E, Collins BK, Farmer BT 2nd, Haverty K, Hill-Drzewi M, Junker HD, Mariana Margarit S, Moss N, Neumann T, Proudfoot JR, Keenan LS, Sekul R, Zhang Q, Li J, Farrow NA. Heim-Riether A, et al. Among authors: gao da. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5321-4. doi: 10.1016/j.bmcl.2009.07.151. Epub 2009 Aug 3. Bioorg Med Chem Lett. 2009. PMID: 19692239
SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability.
Gao DA, Xiong Z, Heim-Riether A, Amodeo L, August EM, Cao X, Ciccarelli L, Collins BK, Harrington K, Haverty K, Hill-Drzewi M, Li X, Liang S, Margarit SM, Moss N, Nagaraja N, Proudfoot J, Roman R, Schlyer S, Keenan LS, Taylor S, Wellenzohn B, Wiedenmayer D, Li J, Farrow NA. Gao DA, et al. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5039-43. doi: 10.1016/j.bmcl.2010.07.036. Epub 2010 Jul 15. Bioorg Med Chem Lett. 2010. PMID: 20675133
Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement.
Moss N, Xiong Z, Burke M, Cogan D, Gao DA, Haverty K, Heim-Riether A, Hickey ER, Nagaraja R, Netherton M, O'Shea K, Ramsden P, Schwartz R, Shih DT, Ward Y, Young E, Zhang Q. Moss N, et al. Among authors: gao da. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7189-93. doi: 10.1016/j.bmcl.2012.09.054. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23084902
Synthesis and SAR studies of indole-based MK2 inhibitors.
Xiong Z, Gao DA, Cogan DA, Goldberg DR, Hao MH, Moss N, Pack E, Pargellis C, Skow D, Trieselmann T, Werneburg B, White A. Xiong Z, et al. Among authors: gao da. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1994-9. doi: 10.1016/j.bmcl.2008.01.119. Epub 2008 Feb 6. Bioorg Med Chem Lett. 2008. PMID: 18291646
Discovery and optimization of p38 inhibitors via computer-assisted drug design.
Goldberg DR, Hao MH, Qian KC, Swinamer AD, Gao DA, Xiong Z, Sarko C, Berry A, Lord J, Magolda RL, Fadra T, Kroe RR, Kukulka A, Madwed JB, Martin L, Pargellis C, Skow D, Song JJ, Tan Z, Torcellini CA, Zimmitti CS, Yee NK, Moss N. Goldberg DR, et al. Among authors: gao da. J Med Chem. 2007 Aug 23;50(17):4016-26. doi: 10.1021/jm070415w. Epub 2007 Jul 20. J Med Chem. 2007. PMID: 17658737
Indole Inhibitors of MMP-13 for Arthritic Disorders.
Taylor SJ, Abeywardane A, Liang S, Xiong Z, Proudfoot JR, Farmer BS, Gao DA, Heim-Riether A, Smith-Keenan LL, Muegge I, Yu Y, Zhang Q, Souza D, Panzenbeck M, Goldberg D, Hill-Drzewi M, Margarit M, Collins B, Li JX, Zuvela-Jelaska L, Li J, Farrow NA. Taylor SJ, et al. Among authors: gao da. ACS Omega. 2021 Jul 19;6(29):18635-18650. doi: 10.1021/acsomega.1c01320. eCollection 2021 Jul 27. ACS Omega. 2021. PMID: 34337203 Free PMC article.
Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives.
Wu JP, Emeigh J, Gao DA, Goldberg DR, Kuzmich D, Miao C, Potocki I, Qian KC, Sorcek RJ, Jeanfavre DD, Kishimoto K, Mainolfi EA, Nabozny G Jr, Peng C, Reilly P, Rothlein R, Sellati RH, Woska JR Jr, Chen S, Gunn JA, O'Brien D, Norris SH, Kelly TA. Wu JP, et al. Among authors: gao da. J Med Chem. 2004 Oct 21;47(22):5356-66. doi: 10.1021/jm049657b. J Med Chem. 2004. PMID: 15481974
Diastereoselective Synthesis of α-Quaternary Aziridine-2-carboxylates via Aza-Corey-Chaykovsky Aziridination of N-tert-Butanesulfinyl Ketimino Esters.
Marsini MA, Reeves JT, Desrosiers JN, Herbage MA, Savoie J, Li Z, Fandrick KR, Sader CA, McKibben B, Gao DA, Cui J, Gonnella NC, Lee H, Wei X, Roschangar F, Lu BZ, Senanayake CH. Marsini MA, et al. Among authors: gao da. Org Lett. 2015 Nov 20;17(22):5614-7. doi: 10.1021/acs.orglett.5b02838. Epub 2015 Nov 11. Org Lett. 2015. PMID: 26558319
Carbamoyl Anion Addition to Azirines.
Kerner MJ, Kuttruff CA, Chevliakov M, Buono FG, Gao DA, Krawiec M, Busacca CA, Senanayake CH, Wipf P, Reeves JT. Kerner MJ, et al. Among authors: gao da. Org Lett. 2021 Jun 4;23(11):4396-4399. doi: 10.1021/acs.orglett.1c01334. Epub 2021 May 14. Org Lett. 2021. PMID: 33988373
Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis.
Patel ND, Sieber JD, Tcyrulnikov S, Simmons BJ, Rivalti D, Duvvuri K, Zhang Y, Gao DA, Fandrick KR, Haddad N, Lao KS, Mangunuru HPR, Biswas S, Qu B, Grinberg N, Pennino S, Lee H, Song JJ, Gupton BF, Garg NK, Kozlowski MC, Senanayake CH. Patel ND, et al. Among authors: gao da. ACS Catal. 2018 Nov 2;8(11):10190-10209. doi: 10.1021/acscatal.8b02509. Epub 2018 Sep 20. ACS Catal. 2018. PMID: 30450265 Free PMC article.
70 results