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490 results

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Page 1
The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.
Holmes IP, Gaines S, Watson SP, Lorthioir O, Walker A, Baddeley SJ, Herbert S, Egan D, Convery MA, Singh OM, Gross JW, Strelow JM, Smith RH, Amour AJ, Brown D, Martin SL. Holmes IP, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. doi: 10.1016/j.bmcl.2009.07.155. Epub 2009 Aug 6. Bioorg Med Chem Lett. 2009. PMID: 19703773
Identification of a sulfonamide series of CCR2 antagonists.
Peace S, Philp J, Brooks C, Piercy V, Moores K, Smethurst C, Watson S, Gaines S, Zippoli M, Mookherjee C, Ife R. Peace S, et al. Bioorg Med Chem Lett. 2010 Jul 1;20(13):3961-4. doi: 10.1016/j.bmcl.2010.04.142. Epub 2010 May 7. Bioorg Med Chem Lett. 2010. PMID: 20627722
The identification of novel orally active mGluR5 antagonist GSK2210875.
Pilla M, Andreoli M, Tessari M, Delle-Fratte S, Roth A, Butler S, Brown F, Shah P, Bettini E, Cavallini P, Benedetti R, Minick D, Smith P, Tehan B, D'Alessandro P, Lorthioir O, Ball C, Garzya V, Goodacre C, Watson S. Pilla M, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7521-4. doi: 10.1016/j.bmcl.2010.09.120. Epub 2010 Nov 2. Bioorg Med Chem Lett. 2010. PMID: 21051228
The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.
Rimland J, Dunne A, Hunjan SS, Sasse R, Uings I, Montanari D, Caivano M, Shah P, Standing D, Gray D, Brown D, Cairns W, Trump R, Smith PW, Bertheleme N, D'Alessandro P, Gul S, Vimal M, Smith DN, Watson SP. Rimland J, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2340-3. doi: 10.1016/j.bmcl.2010.01.133. Epub 2010 Feb 4. Bioorg Med Chem Lett. 2010. PMID: 20202837
The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure.
Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP. Holmes IP, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2013-6. doi: 10.1016/j.bmcl.2010.01.090. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20153647
Identification of novel pyrazole acid antagonists for the EP1 receptor.
McKeown SC, Hall A, Giblin GM, Lorthioir O, Blunt R, Lewell XQ, Wilson RJ, Brown SH, Chowdhury A, Coleman T, Watson SP, Chessell IP, Pipe A, Clayton N, Goldsmith P. McKeown SC, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4767-71. doi: 10.1016/j.bmcl.2006.06.086. Epub 2006 Jul 14. Bioorg Med Chem Lett. 2006. PMID: 16843659
Identification of novel glycine sulfonamide antagonists for the EP1 receptor.
McKeown SC, Hall A, Blunt R, Brown SH, Chessell IP, Chowdhury A, Giblin GM, Healy MP, Johnson MR, Lorthioir O, Michel AD, Naylor A, Lewell X, Roman S, Watson SP, Winchester WJ, Wilson RJ. McKeown SC, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1750-4. doi: 10.1016/j.bmcl.2006.12.060. Epub 2006 Dec 22. Bioorg Med Chem Lett. 2007. PMID: 17236765
The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists.
Lunniss GE, Barnes AA, Barton N, Biagetti M, Bianchi F, Blowers SM, Caberlotto LL, Emmons A, Holmes IP, Montanari D, Norris R, Puckey GV, Walters DJ, Watson SP, Willis J. Lunniss GE, et al. Among authors: watson sp. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7341-4. doi: 10.1016/j.bmcl.2010.10.065. Epub 2010 Nov 10. Bioorg Med Chem Lett. 2010. PMID: 21074426
490 results