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154 results

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Page 1
Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity.
Covel JA, Santora VJ, Smith JM, Hayashi R, Gallardo C, Weinhouse MI, Ibarra JB, Schultz JA, Park DM, Estrada SA, Hofilena BJ, Pulley MD, Smith BM, Ren A, Suarez M, Frazer J, Edwards J, Hauser EK, Lorea J, Semple G, Grottick AJ. Covel JA, et al. Among authors: park dm. J Med Chem. 2009 Sep 24;52(18):5603-11. doi: 10.1021/jm900857n. J Med Chem. 2009. PMID: 19722526
Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.
Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Thomsen WJ, Saldana HR, Whelan KT, Menzaghi F, Webb RR, Beeley NR. Smith BM, et al. Among authors: park dm. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1467-70. doi: 10.1016/j.bmcl.2004.12.080. Bioorg Med Chem Lett. 2005. PMID: 15713408
Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Dosa PI, Covel JA, Ren A, Webb RR, Beeley NR, Martin M, Morgan M, Espitia S, Saldana HR, Bjenning C, Whelan KT, Grottick AJ, Menzaghi F, Thomsen WJ. Smith BM, et al. Among authors: park dm. J Med Chem. 2008 Jan 24;51(2):305-13. doi: 10.1021/jm0709034. Epub 2007 Dec 21. J Med Chem. 2008. PMID: 18095642
Identification of biaryl sulfone derivatives as antagonists of the histamine H₃ receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).
Semple G, Santora VJ, Smith JM, Covel JA, Hayashi R, Gallardo C, Ibarra JB, Schultz JA, Park DM, Estrada SA, Hofilena BJ, Smith BM, Ren A, Suarez M, Frazer J, Edwards JE, Hart R, Hauser EK, Lorea J, Grottick AJ. Semple G, et al. Among authors: park dm. Bioorg Med Chem Lett. 2012 Jan 1;22(1):71-5. doi: 10.1016/j.bmcl.2011.11.075. Epub 2011 Nov 30. Bioorg Med Chem Lett. 2012. PMID: 22172695
rWTC-MBTA Vaccine Induces Potent Adaptive Immune Responses Against Glioblastomas via Dynamic Activation of Dendritic Cells.
Wang H, Medina R, Ye J, Zhang Y, Chakraborty S, Valenzuela A, Uher O, Hadrava Vanova K, Sun M, Sang X, Park DM, Zenka J, Gilbert MR, Pacak K, Zhuang Z. Wang H, et al. Among authors: park dm. Adv Sci (Weinh). 2024 Apr;11(14):e2308280. doi: 10.1002/advs.202308280. Epub 2024 Jan 31. Adv Sci (Weinh). 2024. PMID: 38298111 Free PMC article.
TGF-β and BMP signaling are associated with the transformation of glioblastoma to gliosarcoma and then osteosarcoma.
Li A, Hancock JC, Quezado M, Ahn S, Briceno N, Celiku O, Ranjan S, Aboud O, Colwell N, Kim SA, Nduom E, Kuhn S, Park DM, Vera E, Aldape K, Armstrong TS, Gilbert MR. Li A, et al. Among authors: park dm. Neurooncol Adv. 2023 Dec 19;6(1):vdad164. doi: 10.1093/noajnl/vdad164. eCollection 2024 Jan-Dec. Neurooncol Adv. 2023. PMID: 38292240 Free PMC article.
154 results