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The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease.
Wenink MH, Santegoets KC, Roelofs MF, Huijbens R, Koenen HJ, van Beek R, Joosten I, Meyer-Wentrup F, Mathsson L, Ronnelid J, Adema GJ, Bonvini E, Koenig S, van den Berg WB, van Riel PL, Radstake TR. Wenink MH, et al. Among authors: radstake tr. J Immunol. 2009 Oct 1;183(7):4509-20. doi: 10.4049/jimmunol.0900153. Epub 2009 Sep 4. J Immunol. 2009. PMID: 19734236
Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase.
Blom AB, Radstake TR, Holthuysen AE, Slöetjes AW, Pesman GJ, Sweep FG, van de Loo FA, Joosten LA, Barrera P, van Lent PL, van den Berg WB. Blom AB, et al. Among authors: radstake tr. Arthritis Rheum. 2003 Apr;48(4):1002-14. doi: 10.1002/art.10871. Arthritis Rheum. 2003. PMID: 12687542 Free article.
Inhibition of TNF alpha during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNF alpha blockade in rheumatoid arthritis.
van Lieshout AW, Barrera P, Smeets RL, Pesman GJ, van Riel PL, van den Berg WB, Radstake TR. van Lieshout AW, et al. Among authors: radstake tr. Ann Rheum Dis. 2005 Mar;64(3):408-14. doi: 10.1136/ard.2004.023259. Epub 2004 Jul 15. Ann Rheum Dis. 2005. PMID: 15256380 Free PMC article.
353 results