Eddington ND - Search Results

1

Regulation of gene expression in brain tissues of rats repeatedly treated by the highly abused opioid agonist, oxycodone: microarray profiling and gene mapping analysis.

Hassan HE, Myers AL, Lee IJ, Chen H, Coop A, Eddington ND. Hassan HE, et al. Among authors: eddington nd. Drug Metab Dispos. 2010 Jan;38(1):157-67. doi: 10.1124/dmd.109.029199. Drug Metab Dispos. 2010. PMID: 19786507 Free PMC article.

2

Opioids and efflux transporters. Part 1: P-glycoprotein substrate activity of N-substituted analogs of meperidine.

Mercer SL, Hassan HE, Cunningham CW, Eddington ND, Coop A. Mercer SL, et al. Among authors: eddington nd. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1160-2. doi: 10.1016/j.bmcl.2006.12.042. Epub 2006 Dec 21. Bioorg Med Chem Lett. 2007. PMID: 17251015 Free PMC article.

3

Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats.

Hassan HE, Myers AL, Lee IJ, Coop A, Eddington ND. Hassan HE, et al. Among authors: eddington nd. J Pharm Sci. 2007 Sep;96(9):2494-506. doi: 10.1002/jps.20893. J Pharm Sci. 2007. PMID: 17593551 Free PMC article.

4

Differential involvement of P-glycoprotein (ABCB1) in permeability, tissue distribution, and antinociceptive activity of methadone, buprenorphine, and diprenorphine: in vitro and in vivo evaluation.

Hassan HE, Myers AL, Coop A, Eddington ND. Hassan HE, et al. Among authors: eddington nd. J Pharm Sci. 2009 Dec;98(12):4928-40. doi: 10.1002/jps.21770. J Pharm Sci. 2009. PMID: 19370547 Free PMC article.

5

Evaluation of the P-glycoprotein (Abcb1) affinity status of a series of morphine analogs: comparative study with meperidine analogs to identify opioids with minimal P-glycoprotein interactions.

Hassan HE, Mercer SL, Cunningham CW, Coop A, Eddington ND. Hassan HE, et al. Among authors: eddington nd. Int J Pharm. 2009 Jun 22;375(1-2):48-54. doi: 10.1016/j.ijpharm.2009.03.037. Epub 2009 Apr 5. Int J Pharm. 2009. PMID: 19481690 Free PMC article.

6

Repeated administration of oxycodone modifies the gene expression of several drug metabolising enzymes in the hepatic tissue of male Sprague-Dawley rats, including glutathione S-transferase A-5 (rGSTA5) and CYP3A2.

Myers AL, Hassan HE, Lee IJ, Eddington ND. Myers AL, et al. Among authors: eddington nd. J Pharm Pharmacol. 2010 Feb;62(2):189-96. doi: 10.1211/jpp.62.02.0006. J Pharm Pharmacol. 2010. PMID: 20487198

7

Induction of xenobiotic receptors, transporters, and drug metabolizing enzymes by oxycodone.

Hassan HE, Myers AL, Lee IJ, Mason CW, Wang D, Sinz MW, Wang H, Eddington ND. Hassan HE, et al. Among authors: eddington nd. Drug Metab Dispos. 2013 May;41(5):1060-9. doi: 10.1124/dmd.112.050401. Epub 2013 Feb 25. Drug Metab Dispos. 2013. PMID: 23439660

8

Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs.

Cunningham CW, Mercer SL, Hassan HE, Traynor JR, Eddington ND, Coop A. Cunningham CW, et al. Among authors: eddington nd. J Med Chem. 2008 Apr 10;51(7):2316-20. doi: 10.1021/jm701457j. Epub 2008 Feb 27. J Med Chem. 2008. PMID: 18311899 Free PMC article.

9

Opioids and efflux transporters. Part 3: P-glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs.

Mercer SL, Cunningham CW, Eddington ND, Coop A. Mercer SL, et al. Among authors: eddington nd. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3638-40. doi: 10.1016/j.bmcl.2008.04.046. Epub 2008 Apr 25. Bioorg Med Chem Lett. 2008. PMID: 18499452 Free PMC article.

10

Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice.

Coles LD, Lee IJ, Hassan HE, Eddington ND. Coles LD, et al. Among authors: eddington nd. J Pharm Sci. 2009 Aug;98(8):2832-46. doi: 10.1002/jps.21644. J Pharm Sci. 2009. PMID: 19116954

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