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Coupling of liquid chromatography/tandem mass spectrometry and liquid chromatography/solid-phase extraction/NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective ATP-sensitive potassium channel openers.
Gillotin F, Chiap P, Frédérich M, Van Heugen JC, Francotte P, Lebrun P, Pirotte B, de Tullio P. Gillotin F, et al. Among authors: van heugen jc. Drug Metab Dispos. 2010 Feb;38(2):232-40. doi: 10.1124/dmd.109.028928. Epub 2009 Oct 29. Drug Metab Dispos. 2010. PMID: 19875500
Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels.
Constant-Urban C, Charif M, Goffin E, Van Heugen JC, Elmoualij B, Chiap P, Mouithys-Mickalad A, Serteyn D, Lebrun P, Pirotte B, De Tullio P. Constant-Urban C, et al. Among authors: van heugen jc. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5878-81. doi: 10.1016/j.bmcl.2013.08.091. Epub 2013 Sep 6. Bioorg Med Chem Lett. 2013. PMID: 24055044
New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.
Francotte P, Goffin E, Fraikin P, Lestage P, Van Heugen JC, Gillotin F, Danober L, Thomas JY, Chiap P, Caignard DH, Pirotte B, de Tullio P. Francotte P, et al. Among authors: van heugen jc. J Med Chem. 2010 Feb 25;53(4):1700-11. doi: 10.1021/jm901495t. J Med Chem. 2010. PMID: 20108934 Free article.
Pre-study and in-study validation of an ultra-high pressure LC method coupled to tandem mass spectrometry for off-line determination of oxytetracycline in nasal secretions of healthy pigs.
Bimazubute MA, Rozet E, Dizier I, Van Heugen JC, Arancio E, Gustin P, Crommen J, Chiap P. Bimazubute MA, et al. Among authors: van heugen jc. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Aug 1;877(23):2349-57. doi: 10.1016/j.jchromb.2009.01.033. Epub 2009 Jan 31. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19230797
Development of a sensitive liquid chromatography method coupled with a tandem mass spectrometric detection for the clinical analysis of vinflunine and 4-O-deacetyl vinflunine in blood, urine and faeces.
Zorza G, Van Heugen JC, De Graeve J, Puozzo C. Zorza G, et al. Among authors: van heugen jc. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853(1-2):294-302. doi: 10.1016/j.jchromb.2007.03.030. Epub 2007 Mar 31. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17416213
13 results