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Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis.
Plum W, Tschaharganeh DF, Kroy DC, Corsten E, Erschfeld S, Dierssen U, Wasmuth H, Trautwein C, Streetz KL. Plum W, et al. Among authors: tschaharganeh df. Am J Pathol. 2010 May;176(5):2236-46. doi: 10.2353/ajpath.2010.090469. Epub 2010 Apr 9. Am J Pathol. 2010. PMID: 20382701 Free PMC article.
Phosphatidylinositol 4-Kinase III Alpha Governs Cytoskeletal Organization for Invasiveness of Liver Cancer Cells.
Tran CS, Kersten J, Yan J, Breinig M, Huth T, Poth T, Colasanti O, Riedl T, Faure-Dupuy S, Diehl S, Verhoye L, Li TF, Lingemann M, Schult P, Ahlén G, Frelin L, Kühnel F, Vondran FWR, Breuhahn K, Meuleman P, Heikenwälder M, Schirmacher P, Bartenschlager R, Laketa V, Roessler S, Tschaharganeh DF, Sällberg M, Lohmann V. Tran CS, et al. Among authors: tschaharganeh df. Gastroenterology. 2024 Apr 16:S0016-5085(24)00424-4. doi: 10.1053/j.gastro.2024.04.009. Online ahead of print. Gastroenterology. 2024. PMID: 38636680 Free article.
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer.
Zhu C, Soto-Feliciano YM, Morris JP, Huang CH, Koche RP, Ho YJ, Banito A, Chen CW, Shroff A, Tian S, Livshits G, Chen CC, Fennell M, Armstrong SA, Allis CD, Tschaharganeh DF, Lowe SW. Zhu C, et al. Among authors: tschaharganeh df. Elife. 2023 Jun 1;12:e80854. doi: 10.7554/eLife.80854. Elife. 2023. PMID: 37261974 Free PMC article.
A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets.
Li X, Huang CH, Sánchez-Rivera FJ, Kennedy MC, Tschaharganeh DF, Morris JP 4th, Montinaro A, O'Rourke KP, Banito A, Wilkinson JE, Chen CC, Ho YJ, Dow LE, Tian S, Luan W, de Stanchina E, Zhang T, Gray NS, Walczak H, Lowe SW. Li X, et al. Among authors: tschaharganeh df. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2110557119. doi: 10.1073/pnas.2110557119. Epub 2022 Apr 20. Proc Natl Acad Sci U S A. 2022. PMID: 35442775 Free PMC article.
Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer.
Revia S, Seretny A, Wendler L, Banito A, Eckert C, Breuer K, Mayakonda A, Lutsik P, Evert M, Ribback S, Gallage S, Chikh Bakri I, Breuhahn K, Schirmacher P, Heinrich S, Gaida MM, Heikenwälder M, Calvisi DF, Plass C, Lowe SW, Tschaharganeh DF. Revia S, et al. Among authors: tschaharganeh df. Gut. 2022 Aug;71(8):1613-1628. doi: 10.1136/gutjnl-2021-325405. Epub 2021 Sep 11. Gut. 2022. PMID: 34509979 Free PMC article.
Liver Inflammation and Hepatobiliary Cancers.
Leone V, Ali A, Weber A, Tschaharganeh DF, Heikenwalder M. Leone V, et al. Among authors: tschaharganeh df. Trends Cancer. 2021 Jul;7(7):606-623. doi: 10.1016/j.trecan.2021.01.012. Epub 2021 Mar 2. Trends Cancer. 2021. PMID: 33674229 Review.
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