Kukolj G - Search Results

1

Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization.

Goulet S, Poupart MA, Gillard J, Poirier M, Kukolj G, Beaulieu PL. Goulet S, et al. Among authors: kukolj g. Bioorg Med Chem Lett. 2010 Jan 1;20(1):196-200. doi: 10.1016/j.bmcl.2009.10.136. Epub 2009 Nov 4. Bioorg Med Chem Lett. 2010. PMID: 19945870

2

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.

Beaulieu PL, Bös M, Bousquet Y, Fazal G, Gauthier J, Gillard J, Goulet S, LaPlante S, Poupart MA, Lefebvre S, McKercher G, Pellerin C, Austel V, Kukolj G. Beaulieu PL, et al. Among authors: kukolj g. Bioorg Med Chem Lett. 2004 Jan 5;14(1):119-24. doi: 10.1016/j.bmcl.2003.10.023. Bioorg Med Chem Lett. 2004. PMID: 14684311

3

Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.

McKercher G, Beaulieu PL, Lamarre D, LaPlante S, Lefebvre S, Pellerin C, Thauvette L, Kukolj G. McKercher G, et al. Among authors: kukolj g. Nucleic Acids Res. 2004 Jan 22;32(2):422-31. doi: 10.1093/nar/gkh160. Print 2004. Nucleic Acids Res. 2004. PMID: 14739234 Free PMC article.

4

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.

Beaulieu PL, Bös M, Bousquet Y, DeRoy P, Fazal G, Gauthier J, Gillard J, Goulet S, McKercher G, Poupart MA, Valois S, Kukolj G. Beaulieu PL, et al. Among authors: kukolj g. Bioorg Med Chem Lett. 2004 Feb 23;14(4):967-71. doi: 10.1016/j.bmcl.2003.12.032. Bioorg Med Chem Lett. 2004. PMID: 15013003

5

Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy.

LaPlante SR, Jakalian A, Aubry N, Bousquet Y, Ferland JM, Gillard J, Lefebvre S, Poirier M, Tsantrizos YS, Kukolj G, Beaulieu PL. LaPlante SR, et al. Among authors: kukolj g. Angew Chem Int Ed Engl. 2004 Aug 20;43(33):4306-11. doi: 10.1002/anie.200460326. Angew Chem Int Ed Engl. 2004. PMID: 15368379 No abstract available.

6

Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells.

Beaulieu PL, Bousquet Y, Gauthier J, Gillard J, Marquis M, McKercher G, Pellerin C, Valois S, Kukolj G. Beaulieu PL, et al. Among authors: kukolj g. J Med Chem. 2004 Dec 30;47(27):6884-92. doi: 10.1021/jm040134d. J Med Chem. 2004. PMID: 15615537

7

Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase.

Kukolj G, McGibbon GA, McKercher G, Marquis M, Lefèbvre S, Thauvette L, Gauthier J, Goulet S, Poupart MA, Beaulieu PL. Kukolj G, et al. J Biol Chem. 2005 Nov 25;280(47):39260-7. doi: 10.1074/jbc.M506407200. Epub 2005 Sep 27. J Biol Chem. 2005. PMID: 16188890 Free article.

8

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.

Beaulieu PL, Gillard J, Bykowski D, Brochu C, Dansereau N, Duceppe JS, Haché B, Jakalian A, Lagacé L, LaPlante S, McKercher G, Moreau E, Perreault S, Stammers T, Thauvette L, Warrington J, Kukolj G. Beaulieu PL, et al. Among authors: kukolj g. Bioorg Med Chem Lett. 2006 Oct 1;16(19):4987-93. doi: 10.1016/j.bmcl.2006.07.074. Bioorg Med Chem Lett. 2006. PMID: 16908138

9

N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.

Beaulieu PL, Jolicoeur E, Gillard J, Brochu C, Coulombe R, Dansereau N, Duan J, Garneau M, Jakalian A, Kühn P, Lagacé L, LaPlante S, McKercher G, Perrault S, Poirier M, Poupart MA, Stammers T, Thauvette L, Thavonekham B, Kukolj G. Beaulieu PL, et al. Among authors: kukolj g. Bioorg Med Chem Lett. 2010 Feb 1;20(3):857-61. doi: 10.1016/j.bmcl.2009.12.101. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20074949

10

Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: improved drug-like properties through C-2 SAR in three sub-series.

Beaulieu PL, Dansereau N, Duan J, Garneau M, Gillard J, McKercher G, LaPlante S, Lagacée L, Thauvette L, Kukolj G. Beaulieu PL, et al. Among authors: kukolj g. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1825-9. doi: 10.1016/j.bmcl.2010.02.003. Epub 2010 Feb 6. Bioorg Med Chem Lett. 2010. PMID: 20185309

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

77 results

Search Page