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Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
Wennekes T, Meijer AJ, Groen AK, Boot RG, Groener JE, van Eijk M, Ottenhoff R, Bijl N, Ghauharali K, Song H, O'Shea TJ, Liu H, Yew N, Copeland D, van den Berg RJ, van der Marel GA, Overkleeft HS, Aerts JM. Wennekes T, et al. Among authors: groen ak. J Med Chem. 2010 Jan 28;53(2):689-98. doi: 10.1021/jm901281m. J Med Chem. 2010. PMID: 20000679
The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.
Bijl N, Scheij S, Houten S, Boot RG, Groen AK, Aerts JM. Bijl N, et al. Among authors: groen ak. J Pharmacol Exp Ther. 2008 Sep;326(3):849-55. doi: 10.1124/jpet.108.139394. Epub 2008 Jun 12. J Pharmacol Exp Ther. 2008. PMID: 18550691 Free article.
Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.
van Eijk M, Aten J, Bijl N, Ottenhoff R, van Roomen CP, Dubbelhuis PF, Seeman I, Ghauharali-van der Vlugt K, Overkleeft HS, Arbeeny C, Groen AK, Aerts JM. van Eijk M, et al. Among authors: groen ak. PLoS One. 2009;4(3):e4723. doi: 10.1371/journal.pone.0004723. Epub 2009 Mar 23. PLoS One. 2009. PMID: 19305508 Free PMC article.
Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice.
Bietrix F, Lombardo E, van Roomen CP, Ottenhoff R, Vos M, Rensen PC, Verhoeven AJ, Aerts JM, Groen AK. Bietrix F, et al. Among authors: groen ak. Arterioscler Thromb Vasc Biol. 2010 May;30(5):931-7. doi: 10.1161/ATVBAHA.109.201673. Epub 2010 Feb 18. Arterioscler Thromb Vasc Biol. 2010. PMID: 20167657
Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation.
Langeveld M, van den Berg SA, Bijl N, Bijland S, van Roomen CP, Houben-Weerts JH, Ottenhoff R, Houten SM, van Dijk KW, Romijn JA, Groen AK, Aerts JM, Voshol PJ. Langeveld M, et al. Among authors: groen ak. Metabolism. 2012 Jan;61(1):99-107. doi: 10.1016/j.metabol.2011.05.013. Epub 2011 Aug 3. Metabolism. 2012. PMID: 21816446
Glycosphingolipids and insulin resistance.
Aerts JM, Boot RG, van Eijk M, Groener J, Bijl N, Lombardo E, Bietrix FM, Dekker N, Groen AK, Ottenhoff R, van Roomen C, Aten J, Serlie M, Langeveld M, Wennekes T, Overkleeft HS. Aerts JM, et al. Among authors: groen ak. Adv Exp Med Biol. 2011;721:99-119. doi: 10.1007/978-1-4614-0650-1_7. Adv Exp Med Biol. 2011. PMID: 21910085 Review.
Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein.
Vrins CLJ, Ottenhoff R, van den Oever K, de Waart DR, Kruyt JK, Zhao Y, van Berkel TJC, Havekes LM, Aerts JM, van Eck M, Rensen PCN, Groen AK. Vrins CLJ, et al. Among authors: groen ak. J Lipid Res. 2012 Oct;53(10):2017-2023. doi: 10.1194/jlr.M022194. Epub 2012 Jul 16. J Lipid Res. 2012. PMID: 22802462 Free PMC article.
434 results