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Discovery of orally available integrin alpha5beta1 antagonists.
Zischinsky G, Osterkamp F, Vossmeyer D, Zahn G, Scharn D, Zwintscher A, Stragies R. Zischinsky G, et al. Among authors: stragies r. Bioorg Med Chem Lett. 2010 Jan 1;20(1):380-2. doi: 10.1016/j.bmcl.2009.10.073. Epub 2009 Oct 28. Bioorg Med Chem Lett. 2010. PMID: 19910191
SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists.
Zischinsky G, Osterkamp F, Vossmeyer D, Zahn G, Scharn D, Zwintscher A, Stragies R. Zischinsky G, et al. Among authors: stragies r. Bioorg Med Chem Lett. 2010 Jan 1;20(1):65-8. doi: 10.1016/j.bmcl.2009.11.030. Epub 2009 Nov 14. Bioorg Med Chem Lett. 2010. PMID: 19959360
Assessment of the integrin alpha5beta1 antagonist JSM6427 in proliferative vitreoretinopathy using in vitro assays and a rabbit model of retinal detachment.
Zahn G, Volk K, Lewis GP, Vossmeyer D, Stragies R, Heier JS, Daniel PE Jr, Adamis AP, Chapin EA, Fisher SK, Holz FG, Löffler KU, Knolle J. Zahn G, et al. Among authors: stragies r. Invest Ophthalmol Vis Sci. 2010 Feb;51(2):1028-35. doi: 10.1167/iovs.09-3575. Epub 2009 Oct 8. Invest Ophthalmol Vis Sci. 2010. PMID: 19815730
18 results