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A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis.
Deng L, Zhou JF, Sellers RS, Li JF, Nguyen AV, Wang Y, Orlofsky A, Liu Q, Hume DA, Pollard JW, Augenlicht L, Lin EY. Deng L, et al. Among authors: hume da. Am J Pathol. 2010 Feb;176(2):952-67. doi: 10.2353/ajpath.2010.090622. Epub 2009 Dec 30. Am J Pathol. 2010. PMID: 20042677 Free PMC article.
CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure.
Stutchfield BM, Antoine DJ, Mackinnon AC, Gow DJ, Bain CC, Hawley CA, Hughes MJ, Francis B, Wojtacha D, Man TY, Dear JW, Devey LR, Mowat AM, Pollard JW, Park BK, Jenkins SJ, Simpson KJ, Hume DA, Wigmore SJ, Forbes SJ. Stutchfield BM, et al. Among authors: hume da. Gastroenterology. 2015 Dec;149(7):1896-1909.e14. doi: 10.1053/j.gastro.2015.08.053. Epub 2015 Sep 5. Gastroenterology. 2015. PMID: 26344055 Free PMC article.
The mononuclear phagocyte system revisited.
Hume DA, Ross IL, Himes SR, Sasmono RT, Wells CA, Ravasi T. Hume DA, et al. J Leukoc Biol. 2002 Oct;72(4):621-7. J Leukoc Biol. 2002. PMID: 12377929 Review.
Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.
Sasmono RT, Ehrnsperger A, Cronau SL, Ravasi T, Kandane R, Hickey MJ, Cook AD, Himes SR, Hamilton JA, Hume DA. Sasmono RT, et al. Among authors: hume da. J Leukoc Biol. 2007 Jul;82(1):111-23. doi: 10.1189/jlb.1206713. Epub 2007 Apr 16. J Leukoc Biol. 2007. PMID: 17438263
An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation.
MacDonald KP, Palmer JS, Cronau S, Seppanen E, Olver S, Raffelt NC, Kuns R, Pettit AR, Clouston A, Wainwright B, Branstetter D, Smith J, Paxton RJ, Cerretti DP, Bonham L, Hill GR, Hume DA. MacDonald KP, et al. Among authors: hume da. Blood. 2010 Nov 11;116(19):3955-63. doi: 10.1182/blood-2010-02-266296. Epub 2010 Aug 3. Blood. 2010. PMID: 20682855 Free article.
457 results