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Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson's disease.
Ghosh B, Antonio T, Reith ME, Dutta AK. Ghosh B, et al. J Med Chem. 2010 Mar 11;53(5):2114-25. doi: 10.1021/jm901618d. J Med Chem. 2010. PMID: 20146482 Free PMC article.
Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action.
Biswas S, Zhang S, Fernandez F, Ghosh B, Zhen J, Kuzhikandathil E, Reith ME, Dutta AK. Biswas S, et al. Among authors: ghosh b. J Med Chem. 2008 Jan 10;51(1):101-17. doi: 10.1021/jm070860r. Epub 2007 Dec 12. J Med Chem. 2008. PMID: 18072730
Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.
Biswas S, Hazeldine S, Ghosh B, Parrington I, Kuzhikandathil E, Reith ME, Dutta AK. Biswas S, et al. Among authors: ghosh b. J Med Chem. 2008 May 22;51(10):3005-19. doi: 10.1021/jm701524h. Epub 2008 Apr 12. J Med Chem. 2008. PMID: 18410082
Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids.
Sharma PK, Balwani S, Mathur D, Malhotra S, Singh BK, Prasad AK, Len C, Van der Eycken EV, Ghosh B, Richards NG, Parmar VS. Sharma PK, et al. Among authors: ghosh b. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1520-6. doi: 10.3109/14756366.2016.1151015. Epub 2016 May 5. J Enzyme Inhib Med Chem. 2016. PMID: 27146339
1,469 results