Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.
Agís-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, Guidotti A.
Agís-Balboa RC, et al. Among authors: guidotti a.
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18736-41. doi: 10.1073/pnas.0709419104. Epub 2007 Nov 14.
Proc Natl Acad Sci U S A. 2007.
PMID: 18003893
Free PMC article.
Allopregnanolone (ALLO), synthesized by pyramidal neurons, is a potent positive allosteric modulator of the action of GABA at GABA(A) receptors expressing specific neurosteroid binding sites. ...In the cortex, hippocampus, and amygdala, these enzymes are colocalized …
Allopregnanolone (ALLO), synthesized by pyramidal neurons, is a potent positive allosteric modulator of the action of GABA at GABA( …