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Ex Vivo and In Vivo Lentivirus-Mediated Transduction of Airway Epithelial Progenitor Cells.
Leoni G, Wasowicz MY, Chan M, Meng C, Farley R, Brody SL, Inoue M, Hasegawa M, Alton EW, Griesenbach U. Leoni G, et al. Among authors: farley r. Curr Gene Ther. 2015;15(6):581-90. doi: 10.2174/1566523215666151016123625. Curr Gene Ther. 2015. PMID: 26471068 Free article.
A key challenge in pulmonary gene therapy for cystic fibrosis is to provide long-term correction of the genetic defect. This may be achievable by targeting airway epithelial stem/progenitor cells with an integrating vector. ...
A key challenge in pulmonary gene therapy for cystic fibrosis is to provide long-term correction of the genetic defect. This may be a …
Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations.
Delaney SJ, Alton EW, Smith SN, Lunn DP, Farley R, Lovelock PK, Thomson SA, Hume DA, Lamb D, Porteous DJ, Dorin JR, Wainwright BJ. Delaney SJ, et al. Among authors: farley r. EMBO J. 1996 Mar 1;15(5):955-63. EMBO J. 1996. PMID: 8605891 Free PMC article.
The G551D mutant mice show greatly reduced CFTR-related chloride transport, displaying activity intermediate between that of cftr(mlUNC) replacement ('null') and cftr(mlHGU) insertional (residual activity) mutants and equivalent to approximately 4% of wild-type CFTR activity. The …
The G551D mutant mice show greatly reduced CFTR-related chloride transport, displaying activity intermediate between that of cftr(mlUNC) rep …
Regulation of Na,K-ATPase activity.
McDonough AA, Farley RA. McDonough AA, et al. Among authors: farley ra. Curr Opin Nephrol Hypertens. 1993 Sep;2(5):725-34. doi: 10.1097/00041552-199309000-00006. Curr Opin Nephrol Hypertens. 1993. PMID: 7922215 Review.
The sodium pump Na,K-ATPase, a heterodimer of an alpha catalytic subunit and a beta glycoprotein subunit, is regulated by a wide array of hormonal, autocrine, and paracrine factors. Both short-term acute adjustments of activity and long-term adjustments of sodium pu …
The sodium pump Na,K-ATPase, a heterodimer of an alpha catalytic subunit and a beta glycoprotein subunit, is regulated by a wide array of ho …
Development of a probe for the in vivo measurement of airway humidity during anaesthesia.
Farley RD, Dougall JR, Patel KR. Farley RD, et al. J Biomed Eng. 1990 Jul;12(4):328-32. doi: 10.1016/0141-5425(90)90008-b. J Biomed Eng. 1990. PMID: 2395359
Airway drying can arise during long-term respiration of anaesthetic dry gases and this may have implications for the function of the airway wall. ...
Airway drying can arise during long-term respiration of anaesthetic dry gases and this may have implications for the function of the …
Functional development in the Mauthner cell system of embryos and larvae of the zebra fish.
Eaton RC, Farley RD, Kimmel CB, Schabtach E. Eaton RC, et al. Among authors: farley rd. J Neurobiol. 1977 Mar;8(2):151-72. doi: 10.1002/neu.480080207. J Neurobiol. 1977. PMID: 856948
During these stages the extracellular M-spike is longer in duration and smaller in amplitude than at later times when the cell is more mature morphologically. Our data suggest that long-term inhibitory control of the M-cell system begins to function at about the time of ha …
During these stages the extracellular M-spike is longer in duration and smaller in amplitude than at later times when the cell is more matur …