Pauly T - Search Results

1

The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.

Cheng H, Hoffman J, Le P, Nair SK, Cripps S, Matthews J, Smith C, Yang M, Kupchinsky S, Dress K, Edwards M, Cole B, Walters E, Loh C, Ermolieff J, Fanjul A, Bhat GB, Herrera J, Pauly T, Hosea N, Paderes G, Rejto P. Cheng H, et al. Among authors: pauly t. Bioorg Med Chem Lett. 2010 May 1;20(9):2897-902. doi: 10.1016/j.bmcl.2010.03.032. Epub 2010 Mar 10. Bioorg Med Chem Lett. 2010. PMID: 20363126

2

Structure-based and property-compliant library design of 11β-HSD1 adamantyl amide inhibitors.

Paderes GD, Dress K, Huang B, Elleraas J, Rejto PA, Pauly T. Paderes GD, et al. Among authors: pauly t. Methods Mol Biol. 2011;685:191-215. doi: 10.1007/978-1-60761-931-4_10. Methods Mol Biol. 2011. PMID: 20981525

3

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.

Siu M, Johnson TO, Wang Y, Nair SK, Taylor WD, Cripps SJ, Matthews JJ, Edwards MP, Pauly TA, Ermolieff J, Castro A, Hosea NA, LaPaglia A, Fanjul AN, Vogel JE. Siu M, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3493-7. doi: 10.1016/j.bmcl.2009.05.011. Epub 2009 May 7. Bioorg Med Chem Lett. 2009. PMID: 19473839

4

Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.

Vernier W, Chong W, Rewolinski D, Greasley S, Pauly T, Shaw M, Dinh D, Ferre RA, Meador JW 3rd, Nukui S, Ornelas M, Paz RL, Reyner E. Vernier W, et al. Among authors: pauly t. Bioorg Med Chem. 2010 May 1;18(9):3307-19. doi: 10.1016/j.bmc.2010.03.014. Epub 2010 Mar 11. Bioorg Med Chem. 2010. PMID: 20363633

5

Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket.

Reiter LA, Rizzi JP, Pandit J, Lasut MJ, McGahee SM, Parikh VD, Blake JF, Danley DE, Laird ER, Lopez-Anaya A, Lopresti-Morrow LL, Mansour MN, Martinelli GJ, Mitchell PG, Owens BS, Pauly TA, Reeves LM, Schulte GK, Yocum SA. Reiter LA, et al. Among authors: pauly ta. Bioorg Med Chem Lett. 1999 Jan 18;9(2):127-32. doi: 10.1016/s0960-894x(98)00729-x. Bioorg Med Chem Lett. 1999. PMID: 10021913

6

Structural and biophysical characterization of XIAP BIR3 G306E mutant: insights in protein dynamics and application for fragment-based drug design.

Moore CD, Wu H, Bolaños B, Bergqvist S, Brooun A, Pauly T, Nowlin D. Moore CD, et al. Among authors: pauly t. Chem Biol Drug Des. 2009 Sep;74(3):212-23. doi: 10.1111/j.1747-0285.2009.00862.x. Epub 2009 Jul 29. Chem Biol Drug Des. 2009. PMID: 19660030

7

Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.

Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C, Clark AD Jr, Ryan K, Hickey MJ, Love RA, Hughes SH, Bergqvist S, Arnold E. Himmel DM, et al. Structure. 2009 Dec 9;17(12):1625-1635. doi: 10.1016/j.str.2009.09.016. Structure. 2009. PMID: 20004166 Free PMC article.

8

Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.

Pandit J, Danley DE, Schulte GK, Mazzalupo S, Pauly TA, Hayward CM, Hamanaka ES, Thompson JF, Harwood HJ Jr. Pandit J, et al. Among authors: pauly ta. J Biol Chem. 2000 Sep 29;275(39):30610-7. doi: 10.1074/jbc.M004132200. J Biol Chem. 2000. PMID: 10896663 Free article.

9

Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.

Ekstrom JL, Pauly TA, Carty MD, Soeller WC, Culp J, Danley DE, Hoover DJ, Treadway JL, Gibbs EM, Fletterick RJ, Day YS, Myszka DG, Rath VL. Ekstrom JL, et al. Chem Biol. 2002 Aug;9(8):915-24. doi: 10.1016/s1074-5521(02)00186-2. Chem Biol. 2002. PMID: 12204691

10

A crystallizable form of RIIbeta regulatory domain obtained by limited proteolysis.

Danley DE, Haggan ME, Cunningham D, Fennell KF, Pauly TA, LeMotte PK. Danley DE, et al. Among authors: pauly ta. Acta Crystallogr D Biol Crystallogr. 2000 Aug;56(Pt 8):1038-41. doi: 10.1107/s0907444900007150. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 10944347

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