Melnick A - Search Results

1

A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.

Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Farès C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD Jr, Privé GG, Melnick A. Cerchietti LC, et al. Among authors: melnick a. Cancer Cell. 2010 Apr 13;17(4):400-11. doi: 10.1016/j.ccr.2009.12.050. Cancer Cell. 2010. PMID: 20385364 Free PMC article.

2

In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions.

Melnick A, Ahmad KF, Arai S, Polinger A, Ball H, Borden KL, Carlile GW, Prive GG, Licht JD. Melnick A, et al. Mol Cell Biol. 2000 Sep;20(17):6550-67. doi: 10.1128/MCB.20.17.6550-6567.2000. Mol Cell Biol. 2000. PMID: 10938130 Free PMC article.

3

Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.

Melnick A, Carlile G, Ahmad KF, Kiang CL, Corcoran C, Bardwell V, Prive GG, Licht JD. Melnick A, et al. Mol Cell Biol. 2002 Mar;22(6):1804-18. doi: 10.1128/MCB.22.6.1804-1818.2002. Mol Cell Biol. 2002. PMID: 11865059 Free PMC article.

4

Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.

Ahmad KF, Melnick A, Lax S, Bouchard D, Liu J, Kiang CL, Mayer S, Takahashi S, Licht JD, Privé GG. Ahmad KF, et al. Among authors: melnick a. Mol Cell. 2003 Dec;12(6):1551-64. doi: 10.1016/s1097-2765(03)00454-4. Mol Cell. 2003. PMID: 14690607 Free article.

5

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

Polo JM, Dell'Oso T, Ranuncolo SM, Cerchietti L, Beck D, Da Silva GF, Prive GG, Licht JD, Melnick A. Polo JM, et al. Among authors: melnick a. Nat Med. 2004 Dec;10(12):1329-35. doi: 10.1038/nm1134. Epub 2004 Nov 7. Nat Med. 2004. PMID: 15531890

6

Specific peptides for the therapeutic targeting of oncogenes.

Privé GG, Melnick A. Privé GG, et al. Among authors: melnick a. Curr Opin Genet Dev. 2006 Feb;16(1):71-7. doi: 10.1016/j.gde.2005.12.010. Epub 2005 Dec 27. Curr Opin Genet Dev. 2006. PMID: 16377176 Review.

7

Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas.

Polo JM, Juszczynski P, Monti S, Cerchietti L, Ye K, Greally JM, Shipp M, Melnick A. Polo JM, et al. Among authors: melnick a. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3207-12. doi: 10.1073/pnas.0611399104. Epub 2007 Feb 20. Proc Natl Acad Sci U S A. 2007. PMID: 17360630 Free PMC article.

8

BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms.

Parekh S, Polo JM, Shaknovich R, Juszczynski P, Lev P, Ranuncolo SM, Yin Y, Klein U, Cattoretti G, Dalla Favera R, Shipp MA, Melnick A. Parekh S, et al. Among authors: melnick a. Blood. 2007 Sep 15;110(6):2067-74. doi: 10.1182/blood-2007-01-069575. Epub 2007 Jun 1. Blood. 2007. PMID: 17545502 Free PMC article.

9

Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.

Ranuncolo SM, Polo JM, Dierov J, Singer M, Kuo T, Greally J, Green R, Carroll M, Melnick A. Ranuncolo SM, et al. Among authors: melnick a. Nat Immunol. 2007 Jul;8(7):705-14. doi: 10.1038/ni1478. Epub 2007 Jun 10. Nat Immunol. 2007. PMID: 17558410

10

CtBP is an essential corepressor for BCL6 autoregulation.

Mendez LM, Polo JM, Yu JJ, Krupski M, Ding BB, Melnick A, Ye BH. Mendez LM, et al. Among authors: melnick a. Mol Cell Biol. 2008 Apr;28(7):2175-86. doi: 10.1128/MCB.01400-07. Epub 2008 Jan 22. Mol Cell Biol. 2008. PMID: 18212045 Free PMC article.

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