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The Structures of Gd(III) Chelates Conjugated at the Periphery of 3-(1'-Hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH) Have a Significant Impact on the Imaging and Therapy of Cancer.
Zhang S, Cheruku RR, Dukh M, Tabaczynski W, Patel NJ, White WH 3rd, Missert JR, Spernyak JA, Pandey RK. Zhang S, et al. Among authors: white wh 3rd. ChemMedChem. 2020 Nov 4;15(21):2058-2070. doi: 10.1002/cmdc.202000449. Epub 2020 Oct 14. ChemMedChem. 2020. PMID: 32916033 Free PMC article.
Synthesis, photophysical, electrochemical, tumor-imaging, and phototherapeutic properties of purpurinimide-N-substituted cyanine dyes joined with variable lengths of linkers.
Williams MP, Ethirajan M, Ohkubo K, Chen P, Pera P, Morgan J, White WH 3rd, Shibata M, Fukuzumi S, Kadish KM, Pandey RK. Williams MP, et al. Among authors: white wh 3rd. Bioconjug Chem. 2011 Nov 16;22(11):2283-95. doi: 10.1021/bc200345p. Epub 2011 Oct 21. Bioconjug Chem. 2011. PMID: 21985310 Free PMC article.
Synthesis of Tumor-avid Photosensitizer-Gd(III)DTPA conjugates: impact of the number of gadolinium units in T1/T2 relaxivity, intracellular localization, and photosensitizing efficacy.
Goswami LN, White WH 3rd, Spernyak JA, Ethirajan M, Chen Y, Missert JR, Morgan J, Mazurchuk R, Pandey RK. Goswami LN, et al. Among authors: white wh 3rd. Bioconjug Chem. 2010 May 19;21(5):816-27. doi: 10.1021/bc9005305. Bioconjug Chem. 2010. PMID: 20387863 Free PMC article.
Hexylether derivative of pyropheophorbide-a (HPPH) on conjugating with 3gadolinium(III) aminobenzyldiethylenetriaminepentaacetic acid shows potential for in vivo tumor imaging (MR, Fluorescence) and photodynamic therapy.
Spernyak JA, White WH 3rd, Ethirajan M, Patel NJ, Goswami L, Chen Y, Turowski S, Missert JR, Batt C, Mazurchuk R, Pandey RK. Spernyak JA, et al. Among authors: white wh 3rd. Bioconjug Chem. 2010 May 19;21(5):828-35. doi: 10.1021/bc9005317. Bioconjug Chem. 2010. PMID: 20387862 Free PMC article.