Wang J - Search Results

1

The non-nucleoside reverse transcriptase inhibitor efavirenz stimulates replication of human immunodeficiency virus type 1 harboring certain non-nucleoside resistance mutations.

Wang J, Liang H, Bacheler L, Wu H, Deriziotis K, Demeter LM, Dykes C. Wang J, et al. Virology. 2010 Jul 5;402(2):228-37. doi: 10.1016/j.virol.2010.03.018. Epub 2010 Apr 18. Virology. 2010. PMID: 20399480 Free PMC article.

2

The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in replication efficiency.

Wang J, Dykes C, Domaoal RA, Koval CE, Bambara RA, Demeter LM. Wang J, et al. Virology. 2006 May 10;348(2):462-74. doi: 10.1016/j.virol.2006.01.014. Epub 2006 Feb 28. Virology. 2006. PMID: 16504235 Free PMC article.

3

Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture.

Dykes C, Wang J, Jin X, Planelles V, An DS, Tallo A, Huang Y, Wu H, Demeter LM. Dykes C, et al. Among authors: wang j. J Clin Microbiol. 2006 Jun;44(6):1930-43. doi: 10.1128/JCM.02415-05. J Clin Microbiol. 2006. PMID: 16757582 Free PMC article.

4

Relative replication fitness of efavirenz-resistant mutants of HIV-1: correlation with frequency during clinical therapy and evidence of compensation for the reduced fitness of K103N + L100I by the nucleoside resistance mutation L74V.

Koval CE, Dykes C, Wang J, Demeter LM. Koval CE, et al. Among authors: wang j. Virology. 2006 Sep 15;353(1):184-92. doi: 10.1016/j.virol.2006.05.021. Epub 2006 Jun 21. Virology. 2006. PMID: 16797050 Free PMC article.

5

Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions.

Wang J, Bambara RA, Demeter LM, Dykes C. Wang J, et al. J Virol. 2010 Sep;84(18):9377-89. doi: 10.1128/JVI.00618-10. Epub 2010 Jun 30. J Virol. 2010. PMID: 20592075 Free PMC article.

6

Nonnucleoside reverse transcriptase inhibitor-resistant HIV is stimulated by efavirenz during early stages of infection.

Wang J, Zhang G, Bambara RA, Li D, Liang H, Wu H, Smith HM, Lowe NR, Demeter LM, Dykes C. Wang J, et al. J Virol. 2011 Oct;85(20):10861-73. doi: 10.1128/JVI.05116-11. Epub 2011 Aug 10. J Virol. 2011. PMID: 21835788 Free PMC article.

7

L74V increases the reverse transcriptase content of HIV-1 virions with non-nucleoside reverse transcriptase drug-resistant mutations L100I+K103N and K101E+G190S, which results in increased fitness.

Wang J, Li D, Bambara RA, Yang H, Dykes C. Wang J, et al. J Gen Virol. 2013 Jul;94(Pt 7):1597-1607. doi: 10.1099/vir.0.050914-0. Epub 2013 Mar 27. J Gen Virol. 2013. PMID: 23535575 Free PMC article.

8

Reverse transcriptase backbone can alter the polymerization and RNase activities of non-nucleoside reverse transcriptase mutants K101E+G190S.

Wang J, Li D, Bambara RA, Dykes C. Wang J, et al. J Gen Virol. 2013 Oct;94(Pt 10):2297-2308. doi: 10.1099/vir.0.054999-0. Epub 2013 Jun 26. J Gen Virol. 2013. PMID: 23804564 Free PMC article.

9

A strategy to model nonmonotonic dose-response curve and estimate IC50.

Zhang H, Holden-Wiltse J, Wang J, Liang H. Zhang H, et al. Among authors: wang j. PLoS One. 2013 Aug 1;8(8):e69301. doi: 10.1371/journal.pone.0069301. Print 2013. PLoS One. 2013. PMID: 23936323 Free PMC article.

10

HIV vaccine could use a little help.

Wang J, Jin X. Wang J, et al. Hum Vaccin. 2010 Jun;6(6):476-81. doi: 10.4161/hv.6.6.11285. Epub 2010 Jun 1. Hum Vaccin. 2010. PMID: 20671440 Review.

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