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Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
Watterson SH, Xiao Z, Dodd DS, Tortolani DR, Vaccaro W, Potin D, Launay M, Stetsko DK, Skala S, Davis PM, Lee D, Yang X, McIntyre KW, Balimane P, Patel K, Yang Z, Marathe P, Kadiyala P, Tebben AJ, Sheriff S, Chang CY, Ziemba T, Zhang H, Chen BC, DelMonte AJ, Aranibar N, McKinnon M, Barrish JC, Suchard SJ, Murali Dhar TG. Watterson SH, et al. Among authors: delmonte aj. J Med Chem. 2010 May 13;53(9):3814-30. doi: 10.1021/jm100348u. J Med Chem. 2010. PMID: 20405922
Coupling-Condensation Strategy for the Convergent Synthesis of an Imidazole-Fused 2-Aminoquinoline NLRP3 Agonist.
Bi C, Chadwick J, Davies ML, DelMonte AJ, Geng P, Glace AW, Green RA, Gurak JA Jr, Haley MW, He BL, Inankur B, Jamison CR, Joe CL, Kolotuchin S, Lin D, Lou S, Nye J, Ortiz A, Purdum GE, Rosso VW, Shah M, Simmons EM, Stevens JM, Strotman NA, Tan Y, Zhang L. Bi C, et al. Among authors: delmonte aj. J Org Chem. 2023 Jan 6;88(1):384-394. doi: 10.1021/acs.joc.2c02395. Epub 2022 Dec 14. J Org Chem. 2023. PMID: 36516991
A Metal-Free Reductive N-Alkylation of Indoles with Aldehydes.
Clanton NA, Spiller TE, Ortiz E, Gao Z, Rodriguez-Poirier JM, DelMonte AJ, Frantz DE. Clanton NA, et al. Among authors: delmonte aj. Org Lett. 2021 May 7;23(9):3233-3236. doi: 10.1021/acs.orglett.1c00179. Epub 2021 Feb 25. Org Lett. 2021. PMID: 33630601
Normal myoblast fusion requires myoferlin.
Doherty KR, Cave A, Davis DB, Delmonte AJ, Posey A, Earley JU, Hadhazy M, McNally EM. Doherty KR, et al. Among authors: delmonte aj. Development. 2005 Dec;132(24):5565-75. doi: 10.1242/dev.02155. Epub 2005 Nov 9. Development. 2005. PMID: 16280346 Free PMC article.