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Preclinical PK and PD studies on 2'-O-methyl-phosphorothioate RNA antisense oligonucleotides in the mdx mouse model.
Mol Ther. 2010 Jun;18(6):1210-7. doi: 10.1038/mt.2010.72. Epub 2010 Apr 20.
Mol Ther. 2010.
PMID: 20407428
Free PMC article.
In vivo comparison of 2'-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping.
Heemskerk HA, de Winter CL, de Kimpe SJ, van Kuik-Romeijn P, Heuvelmans N, Platenburg GJ, van Ommen GJ, van Deutekom JC, Aartsma-Rus A.
Heemskerk HA, et al. Among authors: heuvelmans n.
J Gene Med. 2009 Mar;11(3):257-66. doi: 10.1002/jgm.1288.
J Gene Med. 2009.
PMID: 19140108
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Systemic administration of PRO051 in Duchenne's muscular dystrophy.
Goemans NM, Tulinius M, van den Akker JT, Burm BE, Ekhart PF, Heuvelmans N, Holling T, Janson AA, Platenburg GJ, Sipkens JA, Sitsen JM, Aartsma-Rus A, van Ommen GJ, Buyse G, Darin N, Verschuuren JJ, Campion GV, de Kimpe SJ, van Deutekom JC.
Goemans NM, et al. Among authors: heuvelmans n.
N Engl J Med. 2011 Apr 21;364(16):1513-22. doi: 10.1056/NEJMoa1011367. Epub 2011 Mar 23.
N Engl J Med. 2011.
PMID: 21428760
Free article.
Clinical Trial.
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Differential requirements for VirB1 and VirB2 during Brucella abortus infection.
den Hartigh AB, Sun YH, Sondervan D, Heuvelmans N, Reinders MO, Ficht TA, Tsolis RM.
den Hartigh AB, et al. Among authors: heuvelmans n.
Infect Immun. 2004 Sep;72(9):5143-9. doi: 10.1128/IAI.72.9.5143-5149.2004.
Infect Immun. 2004.
PMID: 15322008
Free PMC article.
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