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RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels.
Decher N, Streit AK, Rapedius M, Netter MF, Marzian S, Ehling P, Schlichthörl G, Craan T, Renigunta V, Köhler A, Dodel RC, Navarro-Polanco RA, Preisig-Müller R, Klebe G, Budde T, Baukrowitz T, Daut J. Decher N, et al. EMBO J. 2010 Jul 7;29(13):2101-13. doi: 10.1038/emboj.2010.88. Epub 2010 May 11. EMBO J. 2010. PMID: 20461057 Free PMC article.
Chloroquine blocks the Kir4.1 channels by an open-pore blocking mechanism.
Marmolejo-Murillo LG, Aréchiga-Figueroa IA, Moreno-Galindo EG, Navarro-Polanco RA, Rodríguez-Menchaca AA, Cui M, Sánchez-Chapula JA, Ferrer T. Marmolejo-Murillo LG, et al. Eur J Pharmacol. 2017 Apr 5;800:40-47. doi: 10.1016/j.ejphar.2017.02.024. Epub 2017 Feb 20. Eur J Pharmacol. 2017. PMID: 28216048
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.
Rodríguez-Menchaca AA, Navarro-Polanco RA, Ferrer-Villada T, Rupp J, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA. Rodríguez-Menchaca AA, et al. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1364-8. doi: 10.1073/pnas.0708153105. Epub 2008 Jan 23. Proc Natl Acad Sci U S A. 2008. PMID: 18216262 Free PMC article.
45 results