Issaeva N - Search Results

1

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.

Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, Djureinovic T, Issaeva N, Sleeth K, Sharma RA, Helleday T. Gottipati P, et al. Among authors: issaeva n. Cancer Res. 2010 Jul 1;70(13):5389-98. doi: 10.1158/0008-5472.CAN-09-4716. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551068 Free article.

2

6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance.

Issaeva N, Thomas HD, Djureinovic T, Jaspers JE, Stoimenov I, Kyle S, Pedley N, Gottipati P, Zur R, Sleeth K, Chatzakos V, Mulligan EA, Lundin C, Gubanova E, Kersbergen A, Harris AL, Sharma RA, Rottenberg S, Curtin NJ, Helleday T. Issaeva N, et al. Cancer Res. 2010 Aug 1;70(15):6268-76. doi: 10.1158/0008-5472.CAN-09-3416. Epub 2010 Jul 14. Cancer Res. 2010. PMID: 20631063 Free PMC article.

3

RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells.

Sleeth KM, Sørensen CS, Issaeva N, Dziegielewski J, Bartek J, Helleday T. Sleeth KM, et al. Among authors: issaeva n. J Mol Biol. 2007 Oct 12;373(1):38-47. doi: 10.1016/j.jmb.2007.07.068. Epub 2007 Aug 15. J Mol Biol. 2007. PMID: 17765923

4

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

Bryant HE, Petermann E, Schultz N, Jemth AS, Loseva O, Issaeva N, Johansson F, Fernandez S, McGlynn P, Helleday T. Bryant HE, et al. Among authors: issaeva n. EMBO J. 2009 Sep 2;28(17):2601-15. doi: 10.1038/emboj.2009.206. Epub 2009 Jul 23. EMBO J. 2009. PMID: 19629035 Free PMC article.

5

Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

Petermann E, Orta ML, Issaeva N, Schultz N, Helleday T. Petermann E, et al. Among authors: issaeva n. Mol Cell. 2010 Feb 26;37(4):492-502. doi: 10.1016/j.molcel.2010.01.021. Mol Cell. 2010. PMID: 20188668 Free PMC article.

6

SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways.

Gubanova E, Issaeva N, Gokturk C, Djureinovic T, Helleday T. Gubanova E, et al. Among authors: issaeva n. Cell Cycle. 2013 Dec 15;12(24):3770-80. doi: 10.4161/cc.26660. Epub 2013 Oct 4. Cell Cycle. 2013. PMID: 24107632 Free PMC article.

7

Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.

Gubanova E, Brown B, Ivanov SV, Helleday T, Mills GB, Yarbrough WG, Issaeva N. Gubanova E, et al. Among authors: issaeva n. Clin Cancer Res. 2012 Mar 1;18(5):1257-67. doi: 10.1158/1078-0432.CCR-11-2058. Epub 2012 Jan 13. Clin Cancer Res. 2012. PMID: 22247495 Free PMC article.

8

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.

Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Ørntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG. Bartkova J, et al. Among authors: issaeva n. Nature. 2006 Nov 30;444(7119):633-7. doi: 10.1038/nature05268. Nature. 2006. PMID: 17136093

9

Genomic heterogeneity and copy number variant burden are associated with poor recurrence-free survival and 11q loss in human papillomavirus-positive squamous cell carcinoma of the oropharynx.

Schrank TP, Lenze N, Landess LP, Hoyle A, Parker J, Lal A, Sheth S, Chera BS, Patel SN, Hackman TG, Major MB, Issaeva N, Yarbrough WG. Schrank TP, et al. Among authors: issaeva n. Cancer. 2021 Aug 1;127(15):2788-2800. doi: 10.1002/cncr.33504. Epub 2021 Apr 5. Cancer. 2021. PMID: 33819343 Free PMC article.

10

Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer.

Sewell A, Brown B, Biktasova A, Mills GB, Lu Y, Tyson DR, Issaeva N, Yarbrough WG. Sewell A, et al. Among authors: issaeva n. Clin Cancer Res. 2014 May 1;20(9):2300-11. doi: 10.1158/1078-0432.CCR-13-2585. Epub 2014 Mar 5. Clin Cancer Res. 2014. PMID: 24599934 Free PMC article.

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