Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation.
Williams D, Yan BQ, Wang H, Negm L, Sackmann C, Verkuyl C, Rezai-Stevens V, Eid S, Vediya N, Sato C, Watts JC, Wille H, Schmitt-Ulms G.
Williams D, et al.
Sci Rep. 2023 Feb 9;13(1):2337. doi: 10.1038/s41598-023-29559-z.
Sci Rep. 2023.
PMID: 36759538
Free PMC article.
The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid beta peptide (Abeta) in Alzheimer's disease (AD). Missing have been in vivo data in a relevant Abeta amyloidosis model. ...
The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid beta peptide (Abeta) in …